{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T04:14:07Z","timestamp":1770437647296,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,8,29]],"date-time":"2012-08-29T00:00:00Z","timestamp":1346198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Carbodiimide that was generated from the condensation reaction of iminophosphorane with phenylisocyanate was allowed to react with different phosphorus nucleophiles. Thus, the<jats:italic>in situ<\/jats:italic>resulted heterocumulene reacted with dialkylhydrogenphosphonates in tetrahydrofuran (THF)\/FeCl<jats:sub>3<\/jats:sub>\/H<jats:sub>2<\/jats:sub>O system to give fused pyrrole\u2010 (\u224814%) and pyrimidinephosphonates (\u224857%). On the other hand, with<jats:italic>tris<\/jats:italic>\u2010(dialkyl)aminophosphines, the reaction afforded the corresponding hexaalkylphosphinic diamides as a water\u2010sensitive fine powder, quite stable for a few days in a desiccator. When a protonating agent was present in the reaction medium, the reaction was markedly accelerated leading to the formation of the phosphamides. Next, some saturated and unsaturated Horner\u2013Emmons reagents were applied<jats:italic>in situ<\/jats:italic>to the same carbodiimide to obtain more phosphorylated<jats:italic>N<\/jats:italic>\u2010heterocycles. The analgesic and antiinflammatory activities of the newly synthesized compounds were investigated and showed significant activities. Finally, we further estimated the antitumor activity of five new phosphonates against four carcinoma cell lines.<\/jats:p>","DOI":"10.1002\/ardp.201200142","type":"journal-article","created":{"date-parts":[[2012,8,29]],"date-time":"2012-08-29T07:15:07Z","timestamp":1346224507000},"page":"884-895","source":"Crossref","is-referenced-by-count":44,"title":["Carbodiimides in the Synthesis of Enamino\u2010 and \u03b1\u2010Aminophosphonates as Peptidomimetics of Analgesic\/Antiinflammatory and Anticancer Agents"],"prefix":"10.1002","volume":"345","author":[{"given":"Wafaa M.","family":"Abdou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reham F.","family":"Barghash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed S.","family":"Bekheit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,29]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/10426509108029443"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00127a041"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ps.2780300106"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986712800269245"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.743"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2008.03.032"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.3184\/030823409X393646"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00706-007-0806-z"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.3998\/ark.5550190.0008.f06"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00706-005-0403-y"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.2174\/157017806778559536"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00706-011-0492-8"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1860-5397-3-15"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2008.07.036"},{"key":"e_1_2_5_16_2","first-page":"153","volume-title":"Ylides and Imines of Phosphorus","author":"Johnson Wm. 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