{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:09:07Z","timestamp":1771654147988,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,11,25]],"date-time":"2012-11-25T00:00:00Z","timestamp":1353801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Twenty\u2010four new<jats:italic>N<\/jats:italic>\u2010[(4\u2010phenylpiperazin\u20101\u2010yl)\u2010methyl] derivatives of 3,3\u2010diphenyl\u2010 (<jats:bold>7<\/jats:bold>\u2013<jats:bold>18<\/jats:bold>) and 3\u2010ethyl\u20103\u2010methyl\u2010pyrrolidine\u20102,5\u2010dione (<jats:bold>19<\/jats:bold>\u2013<jats:bold>30<\/jats:bold>) were synthesized and evaluated for their anticonvulsant activity in the maximum electroshock (MES) and subcutaneous pentylenetetrazole (<jats:italic>sc<\/jats:italic>PTZ) seizure tests. The acute neurological toxicity was determined using the rotorod screen. Eleven compounds were active and revealed protection only in electrically induced seizures (MES). In the whole series the most effective compound was<jats:italic>N<\/jats:italic>\u2010[{4\u2010(3\u2010trifluoromethylphenyl)\u2010piperazin\u20101\u2010yl}\u2010methyl]\u20103,3\u2010diphenyl\u2010pyrrolidine\u20102,5\u2010dione (<jats:bold>14<\/jats:bold>) with an ED<jats:sub>50<\/jats:sub>value of 30.3\u2009mg\/kg (<jats:italic>p.o.<\/jats:italic>rats) in the MES test. To explain the possible mechanism of action, for chosen active derivatives<jats:bold>7<\/jats:bold>,<jats:bold>8<\/jats:bold>,<jats:bold>9<\/jats:bold>,<jats:bold>11<\/jats:bold>,<jats:bold>14<\/jats:bold>,<jats:bold>23<\/jats:bold>, and<jats:bold>26<\/jats:bold>, their influence on Na<jats:sub>V<\/jats:sub>1.2 sodium channel currents was evaluated<jats:italic>in vitro<\/jats:italic>. The crystallographic structures for several molecules (<jats:bold>8<\/jats:bold>,<jats:bold>10<\/jats:bold>, and<jats:bold>11<\/jats:bold>) were solved.<\/jats:p>","DOI":"10.1002\/ardp.201200265","type":"journal-article","created":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T09:24:35Z","timestamp":1353921875000},"page":"71-82","source":"Crossref","is-referenced-by-count":18,"title":["Synthesis and Anticonvulsant Properties of New<i>N<\/i>\u2010Mannich Bases Derived from 3,3\u2010Diphenyl\u2010 and 3\u2010Ethyl\u20103\u2010methyl\u2010pyrrolidine\u20102,5\u2010diones. 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