{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T06:01:55Z","timestamp":1760853715568},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T00:00:00Z","timestamp":1378857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec><jats:label \/><jats:p>Two new series of benzenesulfonamide (<jats:bold>4a<\/jats:bold>\u2013<jats:bold>f<\/jats:bold>, <jats:bold>5a<\/jats:bold>\u2013<jats:bold>b<\/jats:bold>, <jats:bold>6<\/jats:bold>, <jats:bold>7<\/jats:bold>) and 1,2\u2010benzisothiazol\u20103(2<jats:italic>H<\/jats:italic>)\u2010one\u20101,1\u2010dioxide (<jats:bold>9a<\/jats:bold>\u2013<jats:bold>c<\/jats:bold>, <jats:bold>10<\/jats:bold>, <jats:bold>12a<\/jats:bold>\u2013<jats:bold>d<\/jats:bold>) derivatives were prepared starting from saccharin sodium. The novel compounds were characterized using elemental analyses and different spectroscopic methods. Assessment of the antiviral activities of these novel compounds against a broad panel of viruses in different cell cultures revealed that only the thiazole derivatives belonging to the benzisothiazol\u20103(2<jats:italic>H<\/jats:italic>)\u2010one\u20101,1\u2010dioxide series are the active ones. All thiazole derivatives <jats:bold>12a<\/jats:bold>\u2013<jats:bold>d<\/jats:bold> showed activity against both varicella\u2010zoster virus, especially TK<jats:sup>\u2212<\/jats:sup> VZV strain 07\u20101, and the cytomegalovirus strains AD\u2010169 and Davis in human embryonic lung (HEL) cell culture.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ardp.201300110","type":"journal-article","created":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T13:10:02Z","timestamp":1378905002000},"page":"733-742","source":"Crossref","is-referenced-by-count":14,"title":["Synthesis of Some New Benzisothiazolone and Benzenesulfonamide Derivatives of Biological Interest Starting from Saccharin Sodium"],"prefix":"10.1002","volume":"346","author":[{"given":"Osama I.","family":"El\u2010Sabbagh","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Pharmaceutical Chemistry Department Taif University Taif Saudi Arabia"},{"name":"Faculty of Pharmacy Medicinal Chemistry Department Zagazig University Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(02)00103-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04638-9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2007.11.120"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2009.03.038"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-009-9248-y"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.11.005"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.4.998"},{"key":"e_1_2_6_9_1","first-page":"129","volume":"5","author":"Schinazi R. 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