{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:23:29Z","timestamp":1777386209319,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T00:00:00Z","timestamp":1385942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:label\/><jats:p>In an attempt to find a new class of antioxidant agents, a series of pyrazole, pyridopyrazoltriazine, pyrazolotriazine, isoxazole, and pyridine\u2010containing products were prepared, starting with curcumin and appropriate chemical reagents. Thus, curcumin <jats:bold>1<\/jats:bold> undergoes coupling reaction with diazonium salts <jats:bold>2<\/jats:bold>\u2013<jats:bold>5<\/jats:bold> to afford the corresponding 4\u2010arylazo derivatives <jats:bold>6<\/jats:bold>\u2013<jats:bold>9<\/jats:bold>. Heating of <jats:bold>6<\/jats:bold> and\/or <jats:bold>7<\/jats:bold> in acetic acid furnished the corresponding pyrazolotriazines <jats:bold>10<\/jats:bold> and <jats:bold>11<\/jats:bold>. Also, pyrazole and isoxazole derivatives were obtained upon treatment of <jats:bold>10<\/jats:bold> with hydrazines or hydroxylamine hydrochloride. Furthermore, multicomponent reaction of <jats:bold>10<\/jats:bold> with malononitrile\/CH<jats:sub>3<\/jats:sub>COONH<jats:sub>4<\/jats:sub> or phenacylpyridinium iodide\/CH<jats:sub>3<\/jats:sub>COONH<jats:sub>4<\/jats:sub> produced the corresponding bispyridines <jats:bold>16<\/jats:bold> and <jats:bold>17<\/jats:bold>, respectively. Furthermore, condensation of <jats:bold>10<\/jats:bold> with guanidine nitrate or thiourea gave the corresponding pyrimidines <jats:bold>18<\/jats:bold> and <jats:bold>19<\/jats:bold>, respectively. Finally, other curcumin derivatives were obtained on condensation of <jats:bold>1<\/jats:bold> with isatins and pyrazole\u20104\u2010aldehyde. The newly synthesized compounds were evaluated as antioxidant agents. The results showed clearly that most of the compounds exhibited good activities, except for compounds <jats:bold>9<\/jats:bold> and <jats:bold>12<\/jats:bold>. Compounds <jats:bold>1<\/jats:bold>, <jats:bold>3<\/jats:bold>, <jats:bold>15<\/jats:bold>, and <jats:bold>23<\/jats:bold> exhibited high protection against DNA damage induced by the bleomycine\u2013iron complex.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ardp.201300203","type":"journal-article","created":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T07:46:05Z","timestamp":1385970365000},"page":"123-133","source":"Crossref","is-referenced-by-count":12,"title":["Synthesis, Characterization, and Antioxidant and Bleomycin\u2010Dependent <scp>DNA<\/scp> Damage Evaluation of Curcumin Analogs"],"prefix":"10.1002","volume":"347","author":[{"given":"Mohamed H. M.","family":"Helal","sequence":"first","affiliation":[{"name":"Faculty of Arts and Science Department of Chemistry Northern Border University Rafha Saudi Arabia"},{"name":"Faculty of Science Department of Chemistry Al\u2010Azhar University Nasr City Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia S.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Faculty of Education Department of Nutrition Northern Border University Rafha Saudi Arabia"},{"name":"Department of Chemistry National Institute of Oceanography and Fisheres Alx Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed S.","family":"Elwessaly","sequence":"additional","affiliation":[{"name":"Department of Nutrition Northern Border University Arar Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yossry A.","family":"Ammar","sequence":"additional","affiliation":[{"name":"Faculty of Science Department of Chemistry Al\u2010Azhar University Nasr City Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-012-0116-9"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2007.09.095"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408690490424702"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762001000500026"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/107555303321223035"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(01)00183-X"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00230.2002"},{"key":"e_1_2_5_9_1","first-page":"274","volume":"7","author":"Rukkumani R.","year":"2004","journal-title":"J. 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