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Defined deprotection steps led, in good yields, to the final target compounds that carry, in position 3, either ester, acid, or amide functions. Thus, a series of novel quinolone nucleoside derivatives was obtained via a convergent synthesis route. Biological tests in human chronic myelogenous leukemia K562 cells exerted an efficient antiproliferative activity for two of them without induction of differentiation. These novel nucleosides deserve further experiments to determine their antiproliferative effects on other CML cell lines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ardp.201300232","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T09:40:26Z","timestamp":1381225226000},"page":"757-765","source":"Crossref","is-referenced-by-count":11,"title":["Synthesis and Antiproliferative Activity of Quinolone Nucleosides Against the Human Myelogenous Leukemia K\u2010562 Cell Line"],"prefix":"10.1002","volume":"346","author":[{"given":"Lena","family":"Wicke","sequence":"first","affiliation":[{"name":"Johann Wolfgang Goethe\u2010Universit\u00e4t Institute of Organic Chemistry and Chemical Biology Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim W.","family":"Engels","sequence":"additional","affiliation":[{"name":"Johann Wolfgang Goethe\u2010Universit\u00e4t Institute of Organic Chemistry and Chemical Biology Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Gambari","sequence":"additional","affiliation":[{"name":"Department of Life Science and Biotechnology Section of Biochemistry and Molecular Biology University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine M.","family":"Saab","sequence":"additional","affiliation":[{"name":"Faculty of Sciences II Chemistry Department Lebanese University Fanar Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp070484"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-077958"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001813-200404000-00009"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2006.09.028"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.08.021"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.09.024"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2006.04.003"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1078\/094471103322004794"},{"key":"e_1_2_6_10_1","first-page":"395","volume":"82","author":"Osti F.","year":"1997","journal-title":"Haematologica"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.02843.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01173.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(00)00297-5"},{"key":"e_1_2_6_14_1","first-page":"826","volume":"88","author":"Chiarabelli C.","year":"2003","journal-title":"Haematologica"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60703-4"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2006.06.004"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-148-2_1"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2006.07.036"},{"key":"e_1_2_6_19_1","first-page":"3","volume":"23","author":"Plunkett W.","year":"1996","journal-title":"Semin. 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