{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T16:54:34Z","timestamp":1789404874274,"version":"build-2803163510"},"reference-count":65,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,4]],"date-time":"2013-12-04T00:00:00Z","timestamp":1386115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:label\/><jats:p>Urotensin II (U\u2010II) is a disulfide bridged peptide hormone identified as the ligand of a G protein\u2010coupled receptor. Human U\u2010II (H\u2010Glu\u2010Thr\u2010Pro\u2010Asp\u2010c[Cys\u2010Phe\u2010Trp\u2010Lys\u2010Tyr\u2010Cys]\u2010Val\u2010OH) has been described as the most potent vasoconstrictor compound identified to date. We have previously identified the compound termed urantide (H\u2010Asp\u2010c[Pen\u2010Phe\u2010DTrp\u2010Orn\u2010Tyr\u2010Cys]\u2010Val\u2010OH), which is the most potent UT receptor (UTR) antagonist described to date. Urantide may have potential clinical value in the treatment of atherosclerosis. In the present study, we studied the conformational preferences of urantide in DPC micelles and developed a urantide\/UTR interaction model. 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