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Inhibition of human (h) carbonic anhydrase (CA) isoenzymes (hCA I, hCA II) and acetylcholine esterase (AChE) was investigated with the synthesized compounds. hCA I and hCA II were inhibited in the low micromolar or sub\u2010micromolar range. The <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values were in the range of 0.91\u20139.56\u2009\u00b5M against hCA I and of 3.70\u201327.88\u2009\u00b5M against hCA II. Sulphamides <jats:bold>11<\/jats:bold>\u2013<jats:bold>13<\/jats:bold> and sulphonamides <jats:bold>14<\/jats:bold>\u2013<jats:bold>16<\/jats:bold> had moderate inhibition capacity toward AChE. These findings suggest the novel sulphamides <jats:bold>11<\/jats:bold>\u2013<jats:bold>13<\/jats:bold> and sulphonamides <jats:bold>14<\/jats:bold>\u2013<jats:bold>16<\/jats:bold> as AChE and CA isoenzyme inhibitory agents.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ardp.201300273","type":"journal-article","created":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T12:29:02Z","timestamp":1384777742000},"page":"68-76","source":"Crossref","is-referenced-by-count":135,"title":["Novel Sulphamides and Sulphonamides Incorporating the Tetralin Scaffold as Carbonic Anhydrase and Acetylcholine Esterase Inhibitors"],"prefix":"10.1002","volume":"347","author":[{"given":"Ak\u0131n","family":"Ak\u0131nc\u0131o\u011flu","sequence":"first","affiliation":[{"name":"Central Researching Laboratory Agri Ibrahim Cecen University Agri Turkey"},{"name":"Faculty of Science Department of Chemistry Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meryem","family":"Topal","sequence":"additional","affiliation":[{"name":"Faculty of Science Department of Chemistry Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lhami","family":"G\u00fcl\u00e7in","sequence":"additional","affiliation":[{"name":"Faculty of Science Department of Chemistry Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00fcleyman","family":"G\u00f6ksu","sequence":"additional","affiliation":[{"name":"Faculty of Science Department of Chemistry Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/138955706777934946"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.10.5.575"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02075"},{"key":"e_1_2_6_5_1","unstructured":"V. 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