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The results revealed that the synthetic farnesylthiosalicylamides displayed significant antitumor activities compared to the positive control FTS. Especially, compound <jats:bold>8f<\/jats:bold> exhibited the strongest antitumor activities with IC<jats:sub>50<\/jats:sub> values of 6.20\u20137.83\u2009\u00b5M, which were one\u2010 to threefold less than those of sorafenib and six\u2010 to tenfold less than that of FTS against each cell line <jats:italic>in vitro<\/jats:italic>. Furthermore, <jats:bold>8f<\/jats:bold> could inhibit the Ras\u2010related signaling pathway and induce SMMC\u20107721 cell apoptosis superior to FTS in a dose\u2010dependent manner. These data indicate that <jats:bold>8f<\/jats:bold> may hold greater promise as therapeutic agent for the intervention of human cancers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ardp.201300325","type":"journal-article","created":{"date-parts":[[2014,1,16]],"date-time":"2014-01-16T13:16:03Z","timestamp":1389878163000},"page":"327-333","source":"Crossref","is-referenced-by-count":6,"title":["Synthesis and Biological Evaluation of Novel Farnesylthiosalicylic Acid Derivatives for Cancer Treatment"],"prefix":"10.1002","volume":"347","author":[{"given":"Yong","family":"Ling","sequence":"first","affiliation":[{"name":"School of Pharmacy Nantong University Nantong P. R. China"},{"name":"State Key Laboratory of Natural Medicines China Pharmaceutical University Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Nantong University Nantong P. R. 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