{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T05:05:15Z","timestamp":1770527115290,"version":"3.49.0"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T00:00:00Z","timestamp":1394064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:label\/><jats:p>Known and novel derivatives including CO, Br, and OH (benzylic and phenolic), and the corresponding benzylic alcohols of (3,4\u2010dimethoxyphenyl)(2,3,4\u2010dimethoxyphenyl)methanone were synthesized, and their inhibitory effects on the carbonic anhydrase (CA) isoenzymes I and II were investigated. CAs are the metalloenzymes catalyzing the reversible hydration of carbon dioxide (CO<jats:sub>2<\/jats:sub>) to bicarbonate (HCO<jats:sub>3<\/jats:sub><jats:sup>\u2212<\/jats:sup>). The inhibitory effects of diphenylmethanone derivatives <jats:bold>5<\/jats:bold>\u2013<jats:bold>18<\/jats:bold> were tested on human CA (hCA, EC 4.2.1.1) isoenzymes (hCA I and hCA II) and they inhibited both isoenzymes at micromolar levels. Compounds <jats:bold>5<\/jats:bold> and <jats:bold>10<\/jats:bold> were found to be the best inhibitors against both CA isoenzymes. According to our data, compound <jats:bold>10<\/jats:bold> was the best inhibitor for isoenzyme hCA I (IC<jats:sub>50<\/jats:sub>\u2009=\u20093.48\u2009\u00b5M, <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub>\u2009=\u20092.19\u2009\u00b5M) whereas compound <jats:bold>5<\/jats:bold> was found to be the best inhibitor for isoenzyme hCA II (IC<jats:sub>50<\/jats:sub>\u2009=\u20091.33\u2009\u00b5M, <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub>\u2009=\u20092.09\u2009\u00b5M). Probably, stable conformations of <jats:bold>5<\/jats:bold> and <jats:bold>10<\/jats:bold> are more convenient for interaction with CA isoenzymes than those of the other compounds.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ardp.201300349","type":"journal-article","created":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T08:02:39Z","timestamp":1394092959000},"page":"354-359","source":"Crossref","is-referenced-by-count":70,"title":["Synthesis and Carbonic Anhydrase Isoenzymes Inhibitory Effects of Brominated Diphenylmethanone and Its Derivatives"],"prefix":"10.1002","volume":"347","author":[{"given":"Yasin","family":"\u00c7etinkaya","sequence":"first","affiliation":[{"name":"Faculty of Science, Department of Chemistry Atat\u00fcrk University Erzurum Turkey"},{"name":"Department of Food Technology Oltu Vocational School, Atat\u00fcrk University Oltu\u2010Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00fclya","family":"G\u00f6\u00e7er","sequence":"additional","affiliation":[{"name":"Central Researching Laboratory Agri Ibrahim Cecen University Agri Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130lhami","family":"G\u00fcl\u00e7in","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Chemistry Atat\u00fcrk University Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Menzek","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Chemistry Atat\u00fcrk University Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/a900201d"},{"key":"e_1_2_6_3_1","first-page":"75","author":"Balayd\u0131n H. 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