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At the molecular level, NDGA is a potent scavenger of reactive oxygen species. Lipoxygenase inhibition by NDGA has been broadly studied over several cell models; however, NDGA exerts other antioxidant properties and cytoprotective effects in non\u2010tumor cells, which are related with its role as modulator of the nuclear factor erythroid 2\u2010related factor 2 (Nrf2)\/antioxidant response element (ARE) antioxidant pathway. In contrast, in tumor cells NDGA exerts pro\u2010apoptotic activity and anti\u2010tumor effects. Different effects of NDGA have been observed in mitochondria, where NDGA prevents mitochondrial damage in non\u2010tumor cells and induces loss of mitochondrial function in tumor cells. Moreover, NDGA exerts beneficial effects in diverse diseases like cancer, renal damage, Huntington's disease, Alzheimer's disease, and other neurodegenerative pathologies. This work represents a critical review about relevant NDGA mechanisms, cellular effects, and signal pathways involved with possible useful effects.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ardp.201400159","type":"journal-article","created":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T13:21:49Z","timestamp":1407331309000},"page":"685-697","source":"Crossref","is-referenced-by-count":37,"title":["Paradoxical Cellular Effects and Biological Role of the Multifaceted Compound Nordihydroguaiaretic Acid"],"prefix":"10.1002","volume":"347","author":[{"given":"Jacqueline","family":"Hern\u00e1ndez\u2010Dami\u00e1n","sequence":"first","affiliation":[{"name":"Faculty of Chemistry, Department of Biology National Autonomous University of Mexico (UNAM) University City D.F. 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