{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T07:11:41Z","timestamp":1696662701196},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T00:00:00Z","timestamp":1410739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec><jats:label \/><jats:p>A series of <jats:italic>tert<\/jats:italic>\u2010butyl\u20105\u2010methylpyrimidin\u2010piperazine derivatives were synthesized and their anti\u2010obesity activities were evaluated. Compounds <jats:bold>4g<\/jats:bold> and <jats:bold>5j<\/jats:bold> were found to have significant effects in down\u2010regulating the triglyceride level of 3T3\u2010L1 adipocytes. <jats:bold>5j<\/jats:bold> exhibited remarkable therapeutic effects on the diet\u2010induced obesity (DIO) mouse model at 20\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>\u2009day<jats:sup>\u22121<\/jats:sup> for 4 weeks by decreasing the weights of body, liver, and fat. <jats:bold>5j<\/jats:bold> also regulated serum biomarkers to appropriate ranges, exerted therapeutic activity of steatosis in liver tissue and ameliorated the obese\u2010related symptoms. In addition, <jats:bold>5j<\/jats:bold> significantly decreased the blood glucose levels in oral glucose tolerance tests and improved the insulin sensitivity in insulin tolerance tests. These results suggest that <jats:bold>5j<\/jats:bold> could be a candidate for obesity treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ardp.201400227","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T08:01:00Z","timestamp":1410768060000},"page":"908-922","source":"Crossref","is-referenced-by-count":3,"title":["Synthesis and Biological Evaluation of <i>tert<\/i>\u2010Butyl\u20105\u2010methylpyrimidin\u2010piperazine Derivatives as Anti\u2010Obesity Agents"],"prefix":"10.1002","volume":"347","author":[{"given":"Jinying","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Biotherapy West China Hospital West China Medical Sichuan University Chengdu P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzhi","family":"Pu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy West China Hospital West China Medical Sichuan University Chengdu P. R. 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