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Pd\u2010C catalysed hydrogenolysis reactions of carbamates or deprotection of the Boc group of the carbamates with CF<jats:sub>3<\/jats:sub>CO<jats:sub>2<\/jats:sub>H afforded seven novel sulfamides. Human carbonic anhydrase (hCA) isoenzymes I and II (hCA I and hCA II) were purified from fresh human blood erythrocytes with one\u2010step affinity chromatography on Sepharose 4B\u2010tyrosine\u2010sulfanilamide. The inhibitory properties of the novel sulfamides on both isoenzymes were determined using the esterase activity with 4\u2010nitrophenyl acetate (NPA) as substrate. The tested novel sulfamides derived from 1\u2010aminoindanes and anilines effectively inhibited hCA I and II competitively in the nanomolar range. Among these compounds, the novel sulfamide derivative <jats:bold>17<\/jats:bold> showed the most potent inhibitory effect against hCA I (<jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub>: 153.88\u2009nM), while sulfamide derivative <jats:bold>26<\/jats:bold> showed the highest inhibitory potential against hCA II (<jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub>: 117.80\u2009nM).<\/jats:p><\/jats:sec>","DOI":"10.1002\/ardp.201400257","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T08:31:32Z","timestamp":1410856292000},"page":"950-957","source":"Crossref","is-referenced-by-count":87,"title":["Synthesis and Carbonic Anhydrase Inhibitory Effects of Novel Sulfamides Derived from 1\u2010Aminoindanes and Anilines"],"prefix":"10.1002","volume":"347","author":[{"given":"Yusuf","family":"Akbaba","sequence":"first","affiliation":[{"name":"Department of Basic Sciences Faculty of Science Erzurum Technical University Erzurum Turkey"},{"name":"Department of Chemistry Faculty of Science Ataturk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enes","family":"Bastem","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Ataturk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fevzi","family":"Topal","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Ataturk University Erzurum Turkey"},{"name":"Department of Medical Services and Techniques Vocational School of Health Services Gumushane University Gumushane Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lhami","family":"G\u00fcl\u00e7in","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Ataturk University Erzurum Turkey"},{"name":"Department of Zoology College of Science King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Mara\u015f","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Ataturk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00fcleyman","family":"G\u00f6ksu","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Ataturk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc42071j"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.01.019"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki134"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02075"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm801432r"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2004.10.042"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm3009426"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(03)00028-3"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm058279n"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.20068"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2467"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1556\/AVet.52.2004.4.4"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/1475636040001704461"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.03.077"},{"key":"e_1_2_5_16_1","first-page":"841","volume":"29","author":"Hisar O.","year":"2005","journal-title":"Turk. 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