{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T07:30:18Z","timestamp":1763105418297},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T00:00:00Z","timestamp":1424736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:label \/><jats:p>New 5\u2010aryl\u201010\u2010(4\u2010(4\u2010methoxyphenyl)thiazole\u20102\u2010yl)\u20109,10\u2010dihydropyrido[2,3\u2010d:5,6\u2010d\u2032]dipyrimidinone\u20102,4,6,8\u2010(1<jats:italic>H<\/jats:italic>,3<jats:italic>H<\/jats:italic>,5<jats:italic>H<\/jats:italic>,7<jats:italic>H<\/jats:italic>)\u2010tetraones <jats:bold>6a<\/jats:bold>\u2013<jats:bold>d<\/jats:bold> were synthesized through one\u2010pot four\u2010component reaction of aldehydes, barbituric acid, and thiazole using Zn<jats:sup>2+<\/jats:sup>@KSF under reflux condition. The key features of this reaction are: incorporating four heterocyclic rings, using a heterogeneous and efficient catalyst, high yield, and easy\u2010to\u2010setup reaction. The structure of the products was confirmed by FT\u2010IR, <jats:sup>1<\/jats:sup>H NMR, and <jats:sup>13<\/jats:sup>C NMR spectra. The antibacterial activities of compounds <jats:bold>6a\u2013d<\/jats:bold> were screened against <jats:italic>Escherichia coli<\/jats:italic>, <jats:italic>Micrococcus luteus<\/jats:italic>, <jats:italic>Pseudomonas aeruginosa<\/jats:italic>, and <jats:italic>Staphylococcus aureus<\/jats:italic> bacterial strains using the zone inhibition method. Also, the 2,2\u2010diphenyl\u20102\u2010picrylhydrazyl (DPPH) radical scavenging activities of compounds <jats:bold>6a\u2013d<\/jats:bold> were evaluated. All compounds showed good antioxidant capacity in comparison to ascorbic acid. The IC<jats:sub>50<\/jats:sub> values of the antioxidant activity were calculated. The proposed mechanism for antioxidant activity is discussed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ardp.201400414","type":"journal-article","created":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T11:07:44Z","timestamp":1424776064000},"page":"275-282","source":"Crossref","is-referenced-by-count":26,"title":["One\u2010Pot Multi\u2010Component Synthesis of 1,4\u2010Dihydropyridines Using Zn<sup>2+<\/sup>@KSF and Evaluating Their Antibacterial and Antioxidant Activities"],"prefix":"10.1002","volume":"348","author":[{"given":"Nosrat O.","family":"Mahmoodi","sequence":"first","affiliation":[{"name":"Department of Chemistry Faculty of Science University of Guilan Rasht Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar","family":"Ramzanpour","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science University of Guilan Rasht Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fateme","family":"Ghanbari Pirbasti","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science University of Guilan Rasht Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(97)00022-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0223-5234(03)00060-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2005.02.147"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(01)00200-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2007.01.016"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm061245a"},{"key":"e_1_2_7_8_1","first-page":"499","volume":"20","author":"Boer R.","year":"1995","journal-title":"Drugs Fut."},{"key":"e_1_2_7_9_1","first-page":"1131","volume":"3","author":"Ono Handkinura M.","year":"1981","journal-title":"Drug Res."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)90807-Y"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.200900243"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.12.006"},{"key":"e_1_2_7_13_1","first-page":"196","volume":"2","author":"Pattan S. 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