{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T02:03:04Z","timestamp":1782698584560,"version":"3.54.5"},"reference-count":67,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T00:00:00Z","timestamp":1431475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:label\/><jats:p>The interest toward sex\u2010related diseases keeps growing through the years. In this review, we focus our attention on erectile dysfunction (ED), a condition that caught much attention especially after the introduction on the market of phosphodiesterase 5 inhibitors such as the well\u2010known sildenafil. Here, we briefly describe both the etiology of ED and the available treatments, examining then extensively some natural derivatives that, coming from traditional medicine, could represent promising starting points for the development of alternative remedies. In fact, herbal remedies from several parts of the world have been traditionally known for long, and were recently reconsidered and are now being studied to demonstrate their eventual potential in the treatment of ED. Among the various examples reported in the literature and reviewed here, plants and extracts containing polyphenols\u2014especially a class of compounds called kraussianones\u2014appear to be particularly effective and promising against ED.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ardp.201500075","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T20:46:27Z","timestamp":1431549987000},"page":"607-614","source":"Crossref","is-referenced-by-count":32,"title":["The Old Made New: Natural Compounds against Erectile Dysfunction"],"prefix":"10.1002","volume":"348","author":[{"given":"Valeria","family":"Pavan","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Mucignat\u2010Caretta","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Redaelli","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Ribaudo","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Zagotto","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences University of Padova Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2012(02)15"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0800-70"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2012.02816.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.01.028"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.2013.31.1.31"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-011-0216-y"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(02)00621-0"},{"key":"e_1_2_9_9_1","unstructured":"http:\/\/www.scopus.com(last accessed February2015)."},{"key":"e_1_2_9_10_1","unstructured":"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/ (last accessed February2015)."},{"key":"e_1_2_9_11_1","unstructured":"http:\/\/www.reaxys.com(last accessed February2015)."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006153422407"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.3.251"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000329598"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.109.008730"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.23.2336"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2009.02426.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2005.20349.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1139\/y91-138"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2005.00094.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/878670"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2013.799665"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-002-0256-5"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728214.2010.480973"},{"key":"e_1_2_9_25_1","unstructured":"Sildenafil Summary of Product Characteristics.http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_\u2010_Product_Information\/human\/000202\/WC500049830.pdf(Accessed January 28 2015)."},{"key":"e_1_2_9_26_1","first-page":"24","volume":"35","author":"Palmer E.","year":"1999","journal-title":"Chem. 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