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The broad spectrum of activities primarily includes antimicrobial, antiviral, anticancer, anti\u2010inflammatory, and analgesic activities. 1,8\u2010Naphthyridine derivatives have also exhibited potential applications in neurological disorders such as Alzheimer's disease, multiple sclerosis, and depression. In addition, these synthetic derivatives have been found to possess activities such as anti\u2010osteoporotic (\u03b1(v)\u03b2(3) antagonists), anti\u2010allergic, antimalarial, gastric antisecretory, bronchodilator, anticonvulsant, anti\u2010hypertensive, platelet aggregation inhibition, anti\u2010oxidant, EGFR inhibition, protein kinase inhibition, ionotropic agent, \u03b2\u20103 antagonist, MDR modulator, adenosine receptor agonist, adrenoceptor antagonist, and pesticide activities. In spite of the widespread application of the 1,8\u2010naphythyridine scaffolds, only a limited number of review articles are available till date. In this review, we attempt to compile and discuss the key data available in the literature for the multiple biological activities of 1,8\u2010naphthyridine derivatives, in a chronological manner. This review compilation (with 199 references) may be helpful in understanding the diverse biological properties of 1,8\u2010naphthyridines and provide insights into their mechanism of action. This may direct future research in the synthesis of new derivatives and exploring this scaffold for other possible biological activities.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ardp.201500237","type":"journal-article","created":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T11:02:45Z","timestamp":1447066965000},"page":"837-860","source":"Crossref","is-referenced-by-count":111,"title":["1,8\u2010Naphthyridine Derivatives: A Review of Multiple Biological Activities"],"prefix":"10.1002","volume":"348","author":[{"given":"Alka","family":"Madaan","sequence":"first","affiliation":[{"name":"Cell Biology Lab Dabur Research Foundation Sahibabad, Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritu","family":"Verma","sequence":"additional","affiliation":[{"name":"Cell Biology Lab Dabur Research Foundation Sahibabad, Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Kumar","sequence":"additional","affiliation":[{"name":"Chemical Research Lab Dabur Research Foundation Sahibabad, Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anu T.","family":"Singh","sequence":"additional","affiliation":[{"name":"Cell Biology Lab Dabur Research Foundation Sahibabad, Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swatantra K.","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, HIMSR and Department of Biotechnology Jamia Hamdard New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manu","family":"Jaggi","sequence":"additional","affiliation":[{"name":"Cell Biology Lab Dabur Research Foundation Sahibabad, Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cber.189302602190"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr60147a004"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00471187"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/BF00766678","volume":"19","author":"Noravyan A. 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