{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T08:14:29Z","timestamp":1772871269633,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T00:00:00Z","timestamp":1444608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:label\/><jats:p>Eighteen new 5\u2010benzylidene\u20103\u2010(4\u2010arylpiperazin\u20101\u2010ylmethyl)\u20102\u2010thioxo\u2010imidazolidin\u20104\u2010ones were designed as hybrid structures from previously reported anticonvulsant compounds, synthesized and tested for anticonvulsant activity. Initial anticonvulsant screening was performed using the strychnine (2\u2009mg\/kg IP) potent generalized\u2010induced seizure and pentylenetetrazole (PTZ) (60\u2009mg\/kg IP) acute clonic\u2010induced convulsion screens in mice. All the molecules were found to be effective in at least one seizure model, compounds<jats:bold>10<\/jats:bold>,<jats:bold>13<\/jats:bold>,<jats:bold>15<\/jats:bold>,<jats:bold>17<\/jats:bold>, and<jats:bold>18<\/jats:bold>were active against both types of seizures induced. Compound<jats:bold>13<\/jats:bold>turned out to be the most active candidate within the strychnine model, having an average survival time of 6\u2009min close to that of the positive control phenytoin, while compound<jats:bold>8<\/jats:bold>showed 100% protection from the induced PTZ seizures, resembling the protection of the positive control phenobarbital. Initial SAR studies for anticonvulsant activity are discussed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ardp.201500272","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T20:42:10Z","timestamp":1444768930000},"page":"868-874","source":"Crossref","is-referenced-by-count":14,"title":["Design and Synthesis of Novel Phenylpiperazine Derivatives as Potential Anticonvulsant Agents"],"prefix":"10.1002","volume":"348","author":[{"given":"Monica M. W.","family":"Habib","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology German University in Cairo Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A. 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