{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:56:07Z","timestamp":1792162567109,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T00:00:00Z","timestamp":1448236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006464","name":"Birla Institute of Technology and Science, Pilani","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006464","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>Ferulic acid has structural similarity with curcumin which is being reported for its monoamine oxidase (MAO) inhibitory activity. Based on this similarity, we designed a series of ferulic acid amides <jats:bold>6a\u2013m<\/jats:bold> and tested for their inhibitory activity on human MAO (hMAO) isoforms. All the compounds were found to inhibit the hMAO isoforms either selectively or non\u2010selectively. Nine compounds (<jats:bold>6a<\/jats:bold>, <jats:bold>6b<\/jats:bold>, <jats:bold>6g\u2013m<\/jats:bold>) were found to inhibit hMAO\u2010B selectively, whereas the other four (<jats:bold>6c<\/jats:bold>\u2013<jats:bold>f<\/jats:bold>) were found to be non\u2010selective. There is a gradual shift from hMAO\u2010B selectivity (<jats:bold>6a<\/jats:bold>,<jats:bold>b<\/jats:bold>) to non\u2010selectivity (<jats:bold>6c<\/jats:bold>\u2013<jats:bold>f<\/jats:bold>) as there is an increase in chain length at the amino terminus. In case of compounds having an aromatic nucleus at the amino terminus, increasing the carbon number between N and the aromatic ring increases the potency as well as selectivity toward hMAO\u2010B. Compounds <jats:bold>6f<\/jats:bold>, <jats:bold>6j<\/jats:bold>, and <jats:bold>6k<\/jats:bold> were subjected to membrane permeability and metabolic stability studies by <jats:italic>in vitro<\/jats:italic> assay methods. They were found to have a better pharmacokinetic profile than curcumin, ferulic acid, and selegiline. In order to understand the structural features responsible for the potency and selectivity of <jats:bold>6k<\/jats:bold>, we carried out a molecular docking simulation study.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ardp.201500317","type":"journal-article","created":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T08:42:51Z","timestamp":1448268171000},"page":"9-19","source":"Crossref","is-referenced-by-count":25,"title":["Monoamine Oxidase Inhibitory Activity of Ferulic Acid Amides: Curcumin\u2010Based Design and Synthesis"],"prefix":"10.1002","volume":"349","author":[{"given":"Vishnu N.","family":"Badavath","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences and Technology Birla Institute of Technology Mesra, Ranchi Jharkhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130pek","family":"Baysal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy Hacettepe University S\u0131hhiye, Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclberk","family":"U\u00e7ar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy Hacettepe University S\u0131hhiye, Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanta K.","family":"Mondal","sequence":"additional","affiliation":[{"name":"TCG Lifesciences Ltd Block\u2010EP&amp;GP, BIPL, Tower\u2010B, Saltlake, Sector\u2010V Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barij N.","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Technology Birla Institute of Technology Mesra, Ranchi Jharkhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatesan","family":"Jayaprakash","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Technology Birla Institute of Technology Mesra, Ranchi Jharkhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,23]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"243","volume":"25","author":"Youdim M. 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