{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T08:43:02Z","timestamp":1780735382426,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T00:00:00Z","timestamp":1449705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>Concerning the role of antioxidant and anti\u2010inflammatory agents for hepatic fibrosis patients, the current study deals with the development of novel chalcone derivatives <jats:bold>5a\u2013i<\/jats:bold> via efficient synthetic methodology in a two\u2010step reaction involving Claisen\u2013Schmidt condensation. The obtained target analogs were screened for <jats:italic>in vitro<\/jats:italic> antioxidant activity by various methods (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>, DPPH, ferrous reducing power, and nitric oxide), where they exhibit considerable radical scavenging activity. These compounds were also evaluated for inhibitory potency against NF\u2010\u03baB activation induced by LPS for the determination of their anti\u2010inflammatory activity. The inhibition values indicate that the entire set of compounds efficiently inhibits the NF\u2010\u03baB activation provoked by LPS. Among the series, compound <jats:bold>5i<\/jats:bold> was identified as the most potent inhibitor of NF\u2010\u03baB, with a relative NF\u2010\u03baB activity of 1.12\u2009\u00b1\u20090.53. It also inhibits various inflammatory mediators, such as TNF\u2010\u03b1, IL\u20101\u03b2, IL\u20106, and PGE<jats:sub>2<\/jats:sub>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ardp.201500349","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T11:25:47Z","timestamp":1449746747000},"page":"63-70","source":"Crossref","is-referenced-by-count":15,"title":["Design and Discovery of Some Novel Chalcones as Antioxidant and Anti\u2010Inflammatory Agents via Attenuating NF\u2010\u03baB"],"prefix":"10.1002","volume":"349","author":[{"given":"Jun","family":"Chu","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery Affiliated Hospital of Logistics University of PAPF Tianjin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Liang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Affiliated Hospital of Logistics University of PAPF Tianjin P. R. 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