{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:38:06Z","timestamp":1773009486505,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T00:00:00Z","timestamp":1464307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:label\/><jats:p>A series of new <jats:italic>N<\/jats:italic>\u2010(substituted)\u20101\u2010methyl\u20102,4\u2010dioxo\u20101,2\u2010dihydroquinazoline\u20103(4<jats:italic>H<\/jats:italic>)\u2010carboxamides were designed, synthesized, and evaluated for their anticonvulsant activity. Most of the synthesized compounds exhibited potent anticonvulsant activities in the maximal electroshock (MES) and pentylenetetrazol (PTZ) test. The most promising compound <jats:bold>4c<\/jats:bold> showed significant anticonvulsant activity with a protective index value of 3.58. The compounds <jats:bold>4a\u2013c<\/jats:bold> were also found to have encouraging anticonvulsant activity in the MES and PTZ screen when compared with the standard drugs, valproate and methaqualone. The same compounds were found to exhibit advanced anticonvulsant activity as well as lower neurotoxicity than the reference drugs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ardp.201600024","type":"journal-article","created":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T10:49:38Z","timestamp":1464346178000},"page":"566-571","source":"Crossref","is-referenced-by-count":35,"title":["Synthesis and Anticonvulsant Activity of <i>N<\/i>\u2010(Substituted)\u20101\u2010methyl\u20102,4\u2010dioxo\u20101,2\u2010dihydroquinazoline\u20103(4<i>H<\/i>)\u2010carboxamides"],"prefix":"10.1002","volume":"349","author":[{"given":"Hemavathi N.","family":"Deepakumari","sequence":"first","affiliation":[{"name":"Department of Chemistry Bharathi College, Bharathinagara Mandya Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bidarur K.","family":"Jayanna","sequence":"additional","affiliation":[{"name":"Department of Chemistry B. N. M. 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