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Key steps involved the solvent\u2010free Claisen\u2013Schmidt condensation of chalcones, and the successful first application of the diazotization\u2013diazocoupling reaction in the synthesis of C\uf8ffN\uf8feN\uf8ffC\u2010linked bischalcones by simple structural modification of<jats:italic>p<\/jats:italic>\u2010aminoacetophenone. The structures of all compounds were confirmed by means of FT\u2010IR,<jats:sup>1<\/jats:sup>H and<jats:sup>13<\/jats:sup>C NMR, ESI\/MS, and elemental analysis. In addition, the newly synthesized compounds were screened for carbonic anhydrase inhibition activities. Almost all bischalcones exhibited moderate\u2010to\u2010good inhibitory activities.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ardp.201600122","type":"journal-article","created":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T12:15:54Z","timestamp":1469016954000},"page":"741-748","source":"Crossref","is-referenced-by-count":45,"title":["Synthesis and Biological Evaluation of Novel Bischalcone Derivatives as Carbonic Anhydrase Inhibitors"],"prefix":"10.1002","volume":"349","author":[{"given":"Tayfun","family":"Arslan","sequence":"first","affiliation":[{"name":"Technical Sciences Vocational School Giresun University Giresun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonca","family":"\u00c7elik","sequence":"additional","affiliation":[{"name":"Department of Chemistry Karadeniz Technical University Trabzon Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habip","family":"\u00c7elik","sequence":"additional","affiliation":[{"name":"Department of Chemistry Agri Ibrahim Cecen University Agri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"\u015eent\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Chemistry Agri Ibrahim Cecen University Agri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurettin","family":"Yayl\u0131","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Karadeniz Technical University Trabzon Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Ekinci","sequence":"additional","affiliation":[{"name":"Department of Agricultural Biotechnology Ondokuz Mayis University Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2006.01.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.04.108"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.10003"},{"key":"e_1_2_7_5_1","first-page":"505","volume":"30","author":"Yayl\u0131 N.","year":"2006","journal-title":"Turk. 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