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The ureas were synthesized from the reactions of substituted phenethylamines with <jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2010dimethylcarbamoyl chloride; then, the synthesized compounds were converted to their corresponding phenolic derivatives via <jats:italic>O<\/jats:italic>\u2010demethylation. hCA I and II were effectively inhibited by the newly synthesized compounds, with <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values in the range of 0.307\u20130.432\u2009nM for hCA I and 0.149\u20130.278\u2009nM for hCA II. On the other hand, the <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> parameters of these compounds for AChE and BChE were determined in the range of 0.129\u20130.434 and 0.095\u20130.207\u2009nM, respectively. Phenolic ureas also showed good antioxidant activities.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ardp.201600183","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T16:10:30Z","timestamp":1478794230000},"page":"944-954","source":"Crossref","is-referenced-by-count":135,"title":["Antioxidant Activity, Acetylcholinesterase, and Carbonic Anhydrase Inhibitory Properties of Novel Ureas Derived from Phenethylamines"],"prefix":"10.1002","volume":"349","author":[{"given":"Kadir","family":"Aksu","sequence":"first","affiliation":[{"name":"Faculty of Arts and Sciences, Department of Chemistry Ordu University Ordu Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00fcnyamin","family":"\u00d6zgeri\u015f","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Basic Sciences Erzurum Technical University Erzurum Turkey"},{"name":"Faculty of Science, Department of Chemistry Ataturk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parham","family":"Taslimi","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Chemistry Ataturk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Naderi","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Chemistry Ataturk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lhami","family":"G\u00fcl\u00e7in","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Chemistry Ataturk University Erzurum Turkey"},{"name":"Department of Zoology, College of Science King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00fcleyman","family":"G\u00f6ksu","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Chemistry Ataturk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm980118e"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/a708019k"},{"key":"e_1_2_6_4_1","first-page":"269","volume":"6","author":"Pochampally J.","year":"2014","journal-title":"Der Pharma Chem"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh029"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0365"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-636X(1999)11:7<529::AID-CHIR3>3.0.CO;2-K"},{"key":"e_1_2_6_8_1","author":"Waugh W. 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