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Tetrabutylammonium fluoride\u2010mediated direct C\uf8ffH arylation of 5\u2010iodouracil nucleosides with furan or 2\u2010heptylfuran gave 5\u2010furyl\u2010substituted nucleosides without the necessity of using the organometallic substrates. These two classes of 5\u2010substituted uracil nucleosides as well their corresponding ester derivatives were tested against a broad range of DNA and RNA viruses and the human immunodeficiency virus (HIV). The 3\u2032,5\u2032\u2010di\u2010<jats:italic>O<\/jats:italic>\u2010acetyl\u20105\u2010(<jats:italic>E<\/jats:italic>)\u2010(1\u2010chloro\u20102\u2010tosylvinyl)\u20102\u2032\u2010deoxyuridine (<jats:bold>24<\/jats:bold>) inhibited the growth of L1210, CEM and HeLa cancer cells in the lower micromolar range. The (\u03b2\u2010chloro)vinyl sulfone <jats:bold>24<\/jats:bold> and 5\u2010(5\u2010heptylfur\u20102\u2010yl)\u20102\u2032\u2010deoxyuridine (<jats:bold>10<\/jats:bold>) displayed micromolar activity against varicella zoster virus (VZV). The 5\u2010(5\u2010heptylfur\u20102\u2010yl) analog <jats:bold>10<\/jats:bold> and its 3\u2032,5\u2032\u2010di\u2010<jats:italic>O<\/jats:italic>\u2010acetyl\u2010protected derivative showed similar activity against the cytomegalovirus (CMV). The 5\u2010(fur\u20102\u2010yl) derivatives of 2\u2032\u2010deoxyuridine and <jats:italic>arabino<\/jats:italic>\u2010uridine inhibited the replication of herpes simplex virus (HSV) TK<jats:sup>+<\/jats:sup> strains while the 5\u2010(5\u2010heptylfur\u20102\u2010yl) derivative <jats:bold>10<\/jats:bold> displayed antiviral activity against the parainfluenza virus.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ardp.201700023","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T11:00:52Z","timestamp":1489748452000},"source":"Crossref","is-referenced-by-count":15,"title":["Antiviral and Cytostatic Evaluation of 5\u2010(1\u2010Halo\u20102\u2010sulfonylvinyl)\u2010 and 5\u2010(2\u2010Furyl)uracil Nucleosides"],"prefix":"10.1002","volume":"350","author":[{"given":"Zhiwei","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry Florida International University Miami FL 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