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The novel NHC precursors were characterized by <jats:sup>1<\/jats:sup>H NMR, <jats:sup>13<\/jats:sup>C NMR, FTIR spectroscopy, and elemental analysis techniques. The enzymes inhibition activities of the NHC precursors were investigated against the cytosolic human carbonic anhydrase I and II isoenzymes (hCA I and II) and the acetylcholinesterase (AChE) enzyme. The inhibition parameters (IC<jats:sub>50<\/jats:sub> and <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values) were calculated by spectrophotometric method. The inhibition constants (<jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub>) were found to be in the range of 166.65\u2013635.38\u2009nM for hCA I, 78.79\u2013246.17\u2009nM for hCA II, and 23.42\u201362.04\u2009nM for AChE. Also, the inhibitory effects of the novel synthesized NHCs were compared to acetazolamide as a clinical CA isoenzymes inhibitor and tacrine as a clinical cholinergic enzymes inhibitor.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ardp.201700045","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T17:40:07Z","timestamp":1493746807000},"source":"Crossref","is-referenced-by-count":79,"title":["Novel NHC Precursors: Synthesis, Characterization, and Carbonic Anhydrase and Acetylcholinesterase Inhibitory Properties"],"prefix":"10.1002","volume":"350","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8496-6782","authenticated-orcid":false,"given":"Ayd\u0131n","family":"Akta\u015f","sequence":"first","affiliation":[{"name":"Faculty of Arts and Sciences, Department of Chemistry In\u00f6n\u00fc University Malatya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parham","family":"Taslimi","sequence":"additional","affiliation":[{"name":"Faculty of Sciences, Department of Chemistry Atat\u00fcrk University Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130lhami","family":"G\u00fcl\u00e7in","sequence":"additional","affiliation":[{"name":"Faculty of Sciences, Department of Chemistry Atat\u00fcrk University Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yetkin","family":"G\u00f6k","sequence":"additional","affiliation":[{"name":"Faculty of Arts and Sciences, Department of Chemistry In\u00f6n\u00fc University Malatya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr900074m"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13384"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2012.01.008"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2013.06.104"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00958972.2013.819092"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10562-014-1453-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11243-014-9877-y"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1134\/S1068162014040049"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1063624"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2016.02.012"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2014.999236"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2015.04.006"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2014.08.005"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1135914"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2016.04.002"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.2558"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1244533"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1198900"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2467"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201600047"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2014.956310"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1064406"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2014.12.054"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(93)90040-Y"},{"key":"e_1_2_7_26_1","first-page":"1060","volume":"31","author":"G\u00fcl\u00e7in \u0130.","year":"2016","journal-title":"J. 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