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The alkynes <jats:bold>30a\u2212d<\/jats:bold> and <jats:bold>31a<\/jats:bold>\u2212<jats:bold>d<\/jats:bold> were applied in the 1,3\u2010dipolar cycloadditions with azides <jats:bold>27<\/jats:bold> and <jats:bold>28<\/jats:bold> to synthesize acyclic 1,2,3\u2010triazole nucleosides. The obtained alkynes and 1,2,3\u2010triazole were evaluated for antiviral activity against a broad range of DNA and RNA viruses. The alkyne <jats:bold>30d<\/jats:bold> showed activity against adenovirus\u20102 (EC<jats:sub>50<\/jats:sub>\u2009=\u20098.3\u2009\u03bcM), while compounds <jats:bold>37a<\/jats:bold> and <jats:bold>37d<\/jats:bold> were also active toward herpes simplex virus\u20101 wild\u2010type and thymidine kinase deficient (HSV\u20101 TK<jats:sup>\u2212<\/jats:sup>) strains (EC<jats:sub>50<\/jats:sub> values in the range of 4.6\u201313.8\u2009\u03bcM). In addition, compounds <jats:bold>30a<\/jats:bold>, <jats:bold>30b<\/jats:bold>, <jats:bold>37b<\/jats:bold>, and <jats:bold>37c<\/jats:bold> exhibited activity toward varicella\u2010zoster virus (VZV) TK<jats:bold><jats:sup>+<\/jats:sup><\/jats:bold> and TK<jats:sup>\u2212<\/jats:sup> strains (EC<jats:sub>50<\/jats:sub>\u2009=\u20092.1\u20139.5\u2009\u03bcM). The compound <jats:bold>30b<\/jats:bold> proved to be the most selective against VZV and displayed marginal activity against human cytomegalovirus (HCMV). Although the compound <jats:bold>30a<\/jats:bold> had improved anti\u2010HCMV activity, the increase in anti\u2010HCMV activity was accompanied by significant toxicity. Compounds <jats:bold>37a<\/jats:bold> and <jats:bold>37d<\/jats:bold> showed inhibitory effects toward the human T lymphocyte (CEM) cell line (IC<jats:sub>50<\/jats:sub>\u2009=\u200921\u2009\u00b1\u20097 and 22\u2009\u00b1\u20091\u2009\u03bcM, respectively), while compound <jats:bold>35<\/jats:bold> exhibited cytostatic activity toward HMEC\u20101 cells (IC<jats:sub>50<\/jats:sub>\u2009=\u200928\u2009\u00b1\u20092\u2009\u03bcM).<\/jats:p><\/jats:sec>","DOI":"10.1002\/ardp.201700166","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T13:50:52Z","timestamp":1501595452000},"source":"Crossref","is-referenced-by-count":11,"title":["Design, Synthesis, and the Biological Evaluation of a New Series of Acyclic 1,2,3\u2010Triazole Nucleosides"],"prefix":"10.1002","volume":"350","author":[{"given":"Iwona E.","family":"G\u0142owacka","sequence":"first","affiliation":[{"name":"Bioorganic Chemistry Laboratory Faculty of Pharmacy Medical University of \u0141\u00f3d\u017a \u0141\u00f3d\u017a Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graciela","family":"Andrei","sequence":"additional","affiliation":[{"name":"Rega Institute for Medical Research KU Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Schols","sequence":"additional","affiliation":[{"name":"Rega Institute for Medical Research KU Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Snoeck","sequence":"additional","affiliation":[{"name":"Rega Institute for Medical Research KU Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Gawron","sequence":"additional","affiliation":[{"name":"Bioorganic Chemistry Laboratory Faculty of Pharmacy Medical University of \u0141\u00f3d\u017a \u0141\u00f3d\u017a Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9783527623112"},{"key":"e_1_2_6_3_1","volume-title":"Antiviral Nucleosides: Chiral Synthesis and Chemotherapy","author":"Chu C. 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