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Oral treatment of hyperglycemic rats with the synthesized biguanide derivatives showed a significant decrease of the elevated glucose in comparison with the anti\u2010diabetic standard drug, metformin. The effects of the synthesized biguanide derivatives on the diabetic properties regarding liver function enzyme activities (AST, ALT, and ALP), lipid profiles (TC, TG, and TL), lipid peroxide, and nitrous oxide as well as histopathological characteristics were investigated and discussed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ardp.201700183","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T08:54:23Z","timestamp":1507884863000},"source":"Crossref","is-referenced-by-count":10,"title":["New Biguanides as Anti\u2010Diabetic Agents, Part II: Synthesis and Anti\u2010Diabetic Properties Evaluation of 1\u2010Arylamidebiguanide Derivatives as Agents of Insulin Resistant Type II Diabetes"],"prefix":"10.1002","volume":"350","author":[{"given":"Wahid M.","family":"Basyouni","sequence":"first","affiliation":[{"name":"National Research Centre Department of Organometallic and Organometalloid Chemistry Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7584-5030","authenticated-orcid":false,"given":"Samir Y.","family":"Abbas","sequence":"additional","affiliation":[{"name":"National Research Centre Department of Organometallic and Organometalloid Chemistry Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed F.","family":"El Shehry","sequence":"additional","affiliation":[{"name":"National Research Centre Department of Pesticide Chemistry Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khairy A.M.","family":"El\u2010Bayouki","sequence":"additional","affiliation":[{"name":"National Research Centre Department of Organometallic and Organometalloid Chemistry Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan F.","family":"Aly","sequence":"additional","affiliation":[{"name":"National Research Centre Department of Therapeutic Chemistry Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azza","family":"Arafa","sequence":"additional","affiliation":[{"name":"National Research Centre Department of Therapeutic Chemistry Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud S.","family":"Soliman","sequence":"additional","affiliation":[{"name":"National Research Centre Department of Therapeutic Chemistry Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm0306273"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.3.917"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3998\/ark.5550190.0011.808","author":"Katritzky A. 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