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All the synthesized compounds were screened for antimicrobial and antitubercular activity. The promising lead compounds <jats:bold>4d<\/jats:bold> and <jats:bold>4e<\/jats:bold> were identified, with MIC values ranging between 3.9 and 7.8\u2009\u00b5g\/mL against different bacterial strains. Compounds <jats:bold>4c\u2013e<\/jats:bold> and <jats:bold>4g<\/jats:bold> also showed good antifungal activities against the tested fungal strain. Among those tested, compound <jats:bold>4e<\/jats:bold> exhibited excellent antitubercular activity (MIC 0.05\u2009\u03bcg\/mL) with a low level of cytotoxicity, suggesting that compound <jats:bold>4e<\/jats:bold> is a promising lead for subsequent investigations in search for new antitubercular agents.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ardp.201700205","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T16:48:51Z","timestamp":1516639731000},"source":"Crossref","is-referenced-by-count":20,"title":["Design, synthesis, and evaluation of new \u03b1\u2010aminonitrile\u2010based benzimidazole biomolecules as potent antimicrobial and antitubercular agents"],"prefix":"10.1002","volume":"351","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4912-7104","authenticated-orcid":false,"given":"Irfan N.","family":"Shaikh","sequence":"first","affiliation":[{"name":"Department of Chemistry SECAB Institute of Engineering and Technology Vijayapur India"},{"name":"P.G. 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