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Only a few classes of the nucleoside and non\u2010nucleoside inhibitors were investigated against TBEV reproduction. Paving the way to previously unexplored areas of anti\u2010TBEV chemical space, we assessed the inhibition of TBEV reproduction in the plaque reduction assay by various compounds derived from cyanothioacetamide and cyanoselenoacetamide. Compounds from seven classes, including 4\u2010(alkylthio)\u20102\u2010aryl\u20103\u2010azaspiro[5.5]undec\u20104\u2010ene\u20101,1,5\u2010tricarbonitriles, 3\u2010arylamino\u20102\u2010(selenazol\u20102\u2010yl)acrylonitriles, ethyl 6\u2010(alkylseleno)\u20105\u2010cyano\u20102\u2010oxo\u20101,2\u2010dihydropyridine\u20103\u2010carboxylates, 6\u2010(alkylseleno)\u20102\u2010oxo\u20101,4,5,6\u2010tetrahydropyridine\u20103\u2010carbonitriles, 2\u2010(alkylseleno)\u20105\u2010oxo\u20101,4,5,6,7,8\u2010hexahydroquinoline\u20103\u2010carbonitriles, 8\u2010selenoxo\u20103,5,7,11\u2010tetraazatricyclo[7.3.1.0<jats:sup>2,7<\/jats:sup>]tridec\u20102\u2010ene\u20101,9\u2010dicarbonitriles, and selenolo[2,3\u2010<jats:italic>b<\/jats:italic>]quinolines, inhibited TBEV reproduction with EC<jats:sub>50<\/jats:sub> values in the micromolar range while showing moderate cytotoxicity and no inhibition of enterovirus reproduction. Thus, new scaffolds with promising anti\u2010TBEV activity were found.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ardp.201700353","type":"journal-article","created":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T19:10:17Z","timestamp":1525115417000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Probing chemical space of tick\u2010borne encephalitis virus reproduction inhibitors with organoselenium compounds"],"prefix":"10.1002","volume":"351","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0597-7705","authenticated-orcid":false,"given":"Alexey A.","family":"Orlov","sequence":"first","affiliation":[{"name":"Institute of Poliomyelitis and Viral Encephalitides, FSBSI Chumakov FSC R&amp;D IBP RAS Poselok Instituta Poliomielita Moscow Russian Federation"},{"name":"Department of Chemistry Lomonosov Moscow State University Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia A.","family":"Eletskaya","sequence":"additional","affiliation":[{"name":"Institute of Poliomyelitis and Viral Encephalitides, FSBSI Chumakov FSC R&amp;D IBP RAS Poselok Instituta Poliomielita Moscow Russian Federation"},{"name":"Department of Fundamental Medicine Lomonosov Moscow State University Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin A.","family":"Frolov","sequence":"additional","affiliation":[{"name":"Kuban State University Krasnodar Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia D.","family":"Golinets","sequence":"additional","affiliation":[{"name":"Institute of Poliomyelitis and Viral Encephalitides, FSBSI Chumakov FSC R&amp;D IBP RAS Poselok Instituta Poliomielita Moscow Russian Federation"},{"name":"Sechenov First Moscow State Medical University Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir A.","family":"Palyulin","sequence":"additional","affiliation":[{"name":"Department of Chemistry Lomonosov Moscow State University Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey G.","family":"Krivokolysko","sequence":"additional","affiliation":[{"name":"Kuban State University Krasnodar Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3029-1035","authenticated-orcid":false,"given":"Liubov I.","family":"Kozlovskaya","sequence":"additional","affiliation":[{"name":"Institute of Poliomyelitis and Viral Encephalitides, FSBSI Chumakov FSC R&amp;D IBP RAS Poselok Instituta Poliomielita Moscow Russian Federation"},{"name":"Sechenov First Moscow State Medical University Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7163-0497","authenticated-orcid":false,"given":"Victor V.","family":"Dotsenko","sequence":"additional","affiliation":[{"name":"Kuban State University Krasnodar Russian Federation"},{"name":"North Caucasus Federal University Stavropol Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0462-2945","authenticated-orcid":false,"given":"Dmitry I.","family":"Osolodkin","sequence":"additional","affiliation":[{"name":"Institute of Poliomyelitis and Viral Encephalitides, FSBSI Chumakov FSC R&amp;D IBP RAS Poselok Instituta Poliomielita Moscow Russian Federation"},{"name":"Department of Chemistry Lomonosov Moscow State University Moscow Russian Federation"},{"name":"Sechenov First Moscow State Medical University Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,30]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Fields Virology","author":"Lindenbach B. 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