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These benzimidazolium salts were characterized by using <jats:sup>1<\/jats:sup>H NMR, <jats:sup>13<\/jats:sup>C NMR, FTIR spectroscopy, and elemental analysis techniques. The molecular and crystal structures of <jats:bold>2f<\/jats:bold> and <jats:bold>2g<\/jats:bold> complexes were obtained by using the single\u2010crystal X\u2010ray diffraction method. The derivatives of these novel NHC precursors were effective inhibitors of \u03b1\u2010glycosidase (AG), the cytosolic carbonic anhydrase I and II isoforms (hCA I and II), butyrylcholinesterase (BChE), and acetylcholinesterase (AChE) with <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values in the range of 1.01\u20132.12\u2009nM for AG, 189.56\u2013402.44\u2009nM for hCA I, 112.50\u2013277.37\u2009nM for hCA II, 95.45\u2013352.58\u2009nM for AChE, and 132.91\u2013571.18\u2009nM for BChE. 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