{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:27:10Z","timestamp":1771036030950,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T00:00:00Z","timestamp":1534982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100003579","name":"American Friends of the Alexander von Humboldt Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003579","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Different studies reported that genetic predisposition or metabolic dysfunction are the risk factors for cancer. Infectious parasitic diseases were listed among factors that predispose to cancer. Because of the resemblance between the life cycle of cancer cells and some parasites, this study aimed to prepare pyran derivatives with cytotoxic and antiprotozoal potencies. Therefore, 7 chromenes, 10 pyranocoumarins, and an unexpected intermediate were obtained from a multi\u2010reagent one\u2010pot reaction. These compounds were evaluated for their cytotoxicity on sensitive and resistant leukemia cancer cells lines and against two protozoan parasites, namely <jats:italic>Trypanosoma cruzi<\/jats:italic> and <jats:italic>Leishmania amazonensis<\/jats:italic> amastigote. Promising cytotoxicity (IC<jats:sub>50<\/jats:sub> values of less than 1\u2009\u00b5M) was obtained for two of the synthetic products (<jats:bold>12<\/jats:bold> and <jats:bold>15<\/jats:bold>). Compound <jats:bold>12<\/jats:bold> induced apoptosis and cell cycle arrest in CCRF\u2010CEM leukemia cells in G0\/G1 while compound <jats:bold>15<\/jats:bold> and doxorubicin induced apoptosis and arrest in the S and G2\/M phases. Ten of these products showed trypanocidal activity, while only five of them were weakly active on <jats:italic>L. amazonensis<\/jats:italic>. Three of the obtained pyrans showed significant cytotoxicity and antitrypanocidal activity, simultaneously. Nevertheless, all antiparasitic compounds revealed potency with low selectivity toward THP\u20101 cells used as host.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ardp.201800100","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T13:20:10Z","timestamp":1535030410000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Prospecting for cytotoxic and antiprotozoal 4\u2010aryl\u20104<i>H<\/i>\u2010chromenes and 10\u2010aryldihydropyrano[2,3\u2010<i>f<\/i>]chromenes"],"prefix":"10.1002","volume":"351","author":[{"given":"Erlon F.","family":"Martin","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences Universidade Federal de Santa Catarina Florian\u00f3polis Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armelle T.","family":"Mbaveng","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Biochemistry University of Dschang Dschang Cameroon"},{"name":"Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry Johannes Gutenberg University Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milene H.","family":"de Moraes","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Parasitology Universidade Federal de Santa Catarina Florian\u00f3polis Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Kuete","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Biochemistry University of Dschang Dschang Cameroon"},{"name":"Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry Johannes Gutenberg University Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maique W.","family":"Biavatti","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Universidade Federal de Santa Catarina Florian\u00f3polis Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Steindel","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Parasitology Universidade Federal de Santa Catarina Florian\u00f3polis Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Efferth","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry Johannes Gutenberg University Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5840-7733","authenticated-orcid":false,"given":"Louis P.","family":"Sandjo","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Universidade Federal de Santa Catarina Florian\u00f3polis Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.1365.3.11"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520610909040437"},{"key":"e_1_2_7_4_1","unstructured":"Cancer.http:\/\/www.who.int\/cancer\/en\/. 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