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All of the compounds obtained were characterized using elemental analysis, FT\u2010IR, <jats:sup>1<\/jats:sup>H NMR, and <jats:sup>13<\/jats:sup>C NMR spectroscopy. The enzyme inhibitory properties of these compounds were tested and the influence of the alkane chain length and the substituents on the phenyl group on the enzyme inhibition activity were examined. The novel Schiff bases and their amine derivatives (<jats:bold>1a\u2013d<\/jats:bold>, <jats:bold>2a\u2013d<\/jats:bold>, <jats:bold>3b\u2013d<\/jats:bold>, <jats:bold>4a\u2013c<\/jats:bold>, <jats:bold>5a\u2013c<\/jats:bold>, <jats:bold>6a<\/jats:bold>, <jats:bold>6c<\/jats:bold>, <jats:bold>6d<\/jats:bold>) were effective inhibitors of the cytosolic carbonic anhydrase I and II isoforms (hCA I and II), and acetylcholinesterase (AChE) with <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values in the range of 159.43\u2009\u00b1\u200930.03 to 563.73\u2009\u00b1\u2009115.30\u2009nM for hCA I, 104.88\u2009\u00b1\u200918.44 to 524.32\u2009\u00b1\u200995.03\u2009nM for hCA II, and 3.95\u2009\u00b1\u20090.74 to 30.83\u2009\u00b1\u20096.81\u2009nM for AChE.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ardp.201800146","type":"journal-article","created":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T05:36:26Z","timestamp":1532324186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Schiff bases and their amines: Synthesis and discovery of carbonic anhydrase and acetylcholinesterase enzymes inhibitors"],"prefix":"10.1002","volume":"351","author":[{"given":"Beyhan","family":"Yi\u011fit","sequence":"first","affiliation":[{"name":"Faculty of Science and Art, Department of Chemistry Ad\u0131yaman University Ad\u0131yaman Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Yi\u011fit","sequence":"additional","affiliation":[{"name":"Faculty of Science and Art, Department of Chemistry Ad\u0131yaman University Ad\u0131yaman Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3171-0633","authenticated-orcid":false,"given":"Parham","family":"Taslimi","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Chemistry Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yetkin","family":"G\u00f6k","sequence":"additional","affiliation":[{"name":"Faculty of Science and Art, Department of Chemistry In\u00f6n\u00fc University Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-1668","authenticated-orcid":false,"given":"\u0130lhami","family":"G\u00fcl\u00e7in","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Chemistry Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,22]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"The Chemistry of the Carbon\u2010Nitrogen Double Bond","author":"Patai S.","year":"1970"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlac.18641310113"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2017.1252752"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules181012264"},{"key":"e_1_2_6_6_1","first-page":"81","volume":"73","author":"Cimerman Z.","year":"2000","journal-title":"Croat. 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