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The synthesis of sulfamides was achieved by the reactions of phenethylamines with <jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2010dimethylsulfamoyl chloride in the presence of Et<jats:sub>3<\/jats:sub>N. The methoxylated sulfamides were converted into their phenolic derivatives with BBr<jats:sub>3<\/jats:sub> for structure\u2013activity relationships. The synthesized sulfamide\/phenolic sulfamide derivatives were investigated as cholinesterase inhibitors and their relative role in AChE versus BChE inhibition was defined. Sulfamide\/phenolic sulfamide derivatives are known as important carbonic anhydrase inhibitors; therefore, the synthesized compounds were investigated for inhibitory effects on both carbonic anhydrase isoenzymes. Additionally, we evaluated four different enzymes, which were inhibited in the low nanomolar range by these compounds. According to the present studies, for AChE, BChE, and carbonic anhydrase I and II, the ranges of results are recorded as 0.027\u20130.076\u2009nM, 0.075\u20130.327\u2009nM, 0.123\u20130.678\u2009nM, and 0.024\u20130.688\u2009nM, respectively.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ardp.201800150","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T05:20:38Z","timestamp":1533619238000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Synthesis of novel sulfamides incorporating phenethylamines and determination of their inhibition profiles against some metabolic enzymes"],"prefix":"10.1002","volume":"351","author":[{"given":"Kadir","family":"Aksu","sequence":"first","affiliation":[{"name":"Faculty of Science, Department of Chemistry Atat\u00fcrk University Erzurum Turkey"},{"name":"Faculty of Arts and Science, Department of Chemistry Ordu University Ordu Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fclya","family":"Ak\u0131nc\u0131o\u011flu","sequence":"additional","affiliation":[{"name":"Faculty of Arts and Science Agri \u0130brahim \u00c7e\u00e7en University Agri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ak\u0131n","family":"Ak\u0131nc\u0131o\u011flu","sequence":"additional","affiliation":[{"name":"Central Researching Laboratory Agri Ibrahim Cecen University Agri Turkey"},{"name":"Vocational School Agri Ibrahim Cecen University Agri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1280-3954","authenticated-orcid":false,"given":"S\u00fcleyman","family":"G\u00f6ksu","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Chemistry Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferhan","family":"T\u00fcmer","sequence":"additional","affiliation":[{"name":"Faculty of Arts and Science, Department of Chemistry Sutcu Imam University Kahramanmaras Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lhami","family":"G\u00fcl\u00e7in","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Chemistry Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2005.03.007"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.181356198"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/36.1.1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr400230c"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-0348-9315-2_9"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/138955706777934946"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21741"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02075"},{"key":"e_1_2_7_10_1","first-page":"198297","volume":"157","author":"Schou S. 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