{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:54:14Z","timestamp":1787068454147,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T00:00:00Z","timestamp":1532995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["1.1.1.1\/16\/A\/290"],"award-info":[{"award-number":["1.1.1.1\/16\/A\/290"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      The spread of drug\u2010resistant malaria parasites urges the search for new antimalarial drugs. Malarial aspartic proteases \u2013 plasmepsins (Plms) \u2013 are differentially expressed in multiple stages of the\n                      <jats:italic>Plasmodium<\/jats:italic>\n                      parasite's lifecycle and are considered as attractive drug targets. We report the development of novel azole\u2010based non\u2010peptidomimetic plasmepsin inhibitors that have been designed by bioisosteric substitution of the amide moiety in the Actelion amino\u2010piperazine inhibitors. The best triazole\u2010based inhibitors show submicromolar potency toward Plm II, which is comparable to that of the parent Actelion compounds. The new inhibitors can be used as a starting point for the development of a resistance\u2010free antimalarial drug targeting the non\u2010digestive Plm IX or X, which are essential for the malaria parasite life cycle.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ardp.201800151","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T08:02:53Z","timestamp":1533110573000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Azole\u2010based non\u2010peptidomimetic plasmepsin inhibitors"],"prefix":"10.1002","volume":"351","author":[{"given":"Linda","family":"Kinena","sequence":"first","affiliation":[{"name":"Latvian Institute of Organic Synthesis Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gundars","family":"Leitis","sequence":"additional","affiliation":[{"name":"Latvian Institute of Organic Synthesis Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iveta","family":"Kanepe\u2010Lapsa","sequence":"additional","affiliation":[{"name":"Latvian Institute of Organic Synthesis Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raitis","family":"Bobrovs","sequence":"additional","affiliation":[{"name":"Latvian Institute of Organic Synthesis Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristaps","family":"Jaudzems","sequence":"additional","affiliation":[{"name":"Latvian Institute of Organic Synthesis Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vita","family":"Ozola","sequence":"additional","affiliation":[{"name":"Latvian Institute of Organic Synthesis Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgars","family":"Suna","sequence":"additional","affiliation":[{"name":"Latvian Institute of Organic Synthesis Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8937-8792","authenticated-orcid":false,"given":"Aigars","family":"Jirgensons","sequence":"additional","affiliation":[{"name":"Latvian Institute of Organic Synthesis Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,31]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"WHO World Malar. 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