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Eight sulfamates derived from menthol (<jats:bold>2a\u2013h<\/jats:bold>) were synthesized. Also, in the other section of this study, novel sulfamate derivatives of menthol were tested against some metabolic enzymes including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and carbonic anhydrase I and II enzymes (hCAs I and II). The newly synthesized novel menthol sulfamate and menthol carbonyl sulfamate derivatives showed <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values in the range of 34.37\u2009\u00b1\u20098.17 to 53.40\u2009\u00b1\u200910.61\u2009nM against hCA I, 12.91\u2009\u00b1\u20094.57 to 38.67\u2009\u00b1\u20096.22\u2009nM against hCA II, 111.17\u2009\u00b1\u200952.36 to 522.86\u2009\u00b1\u2009120.08\u2009nM against AChE, and 50.01\u2009\u00b1\u200911.73 to 109.63\u2009\u00b1\u200950.08\u2009nM against BChE. As a result, the novel menthol sulfamate and menthol carbonyl sulfamate derivatives can be promising Alzheimer's disease drug candidates and novel hCA I and hCA II enzymes inhibitors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ardp.201800209","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T11:46:42Z","timestamp":1537962402000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Novel sulfamate derivatives of menthol: Synthesis, characterization, and cholinesterases and carbonic anhydrase enzymes inhibition properties"],"prefix":"10.1002","volume":"351","author":[{"given":"Shahla","family":"Daryadel","sequence":"first","affiliation":[{"name":"Faculty of Science, Department of Chemistry Ataturk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ufuk","family":"Atmaca","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department 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