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The biological evaluation of the newly synthesized compounds showed that the inhibition of human farnesyltransferase by zinc complexation could be improved with triazine\u2010isoxazole moieties. The replacement of the isoxazole unit by a pyrrolidin\u20102\u2010one was detrimental to the inhibitory activity while the pyrrolidin\u20102\u2010thione derivatives conserved the biological potential. 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