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The obtained yields of the synthesized compounds were moderate (40\u201370%) and these compounds were confirmed by spectral data. These novel pyrazoline derivatives were effective inhibitor compounds of the human carbonic anhydrase I and II isozymes (hCAs I and II) and of the acetylcholinesterase (AChE) enzyme, with <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values in the range of 17.4\u201340.7\u2009nM for hCA I, 16.1\u201355.2\u2009nM for hCA II, and 48.2\u201384.1\u2009nM for AChE. In silico studies were performed on the compounds inhibiting hCA I, hCA II, and AChE receptors. On the basis of the findings, the inhibition profile of the new pyrazoline compounds at the receptors was determined.<\/jats:p>","DOI":"10.1002\/ardp.201800359","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T16:06:24Z","timestamp":1558713984000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Synthesis, characterization, molecular docking and biological activities of novel pyrazoline derivatives"],"prefix":"10.1002","volume":"352","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0538-3157","authenticated-orcid":false,"given":"Fikret","family":"Turkan","sequence":"first","affiliation":[{"name":"Health Services Vocational School Igd\u0131r University Igd\u0131r Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Cetin","sequence":"additional","affiliation":[{"name":"Department of Science Faculty of Education, Mu\u015f Alparslan University Mu\u015f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3171-0633","authenticated-orcid":false,"given":"Parham","family":"Taslimi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Faculty of Science, Bartin University Bartin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halide S.","family":"Karaman","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science, Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lhami","family":"Gul\u00e7in","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science, Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,24]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200600043"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2005.10.145"},{"key":"e_1_2_7_1_4_1","first-page":"133","volume":"107","author":"Joshi S. 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