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The synthesized hybrid molecules were characterized by spectral studies. Compounds <jats:bold>8k\u2010z<\/jats:bold> were screened for their <jats:italic>in vitro<\/jats:italic> anti\u2010TB activity by using the Microplate Alamar Blue assay and for cytotoxicity using the MTT assay. Some of the compounds were found to be most potent against the tested <jats:italic>Mycobacterium tuberculosis<\/jats:italic> H37Rv strain with a MIC of 1.60\u2009\u00b5g\/ml. Further, docking the compounds into the InhA binding pocket showed strong binding interactions and effective overall docking scores were recorded. The drug\u2010likeness and toxicity studies were computed using Molinspiration and Protox, respectively.<\/jats:p>","DOI":"10.1002\/ardp.201900013","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T09:27:15Z","timestamp":1565342835000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Click chemistry based regioselective one\u2010pot synthesis of coumarin\u20103\u2010yl\u2010methyl\u20101,2,3\u2010triazolyl\u20101,2,4\u2010triazol\u20103(4<i>H<\/i>)\u2010ones as newer potent antitubercular agents"],"prefix":"10.1002","volume":"352","author":[{"given":"Shilpa M.","family":"Somagond","sequence":"first","affiliation":[{"name":"Department of Studies in Chemistry Karnatak University Dharwad  Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0384-655X","authenticated-orcid":false,"given":"Ravindra R.","family":"Kamble","sequence":"additional","affiliation":[{"name":"Department of Studies in Chemistry Karnatak University Dharwad  Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen K.","family":"Bayannavar","sequence":"additional","affiliation":[{"name":"Department of Studies in Chemistry Karnatak University Dharwad  Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba Kauser J.","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Department of Studies in Chemistry Karnatak University Dharwad  Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrinivas D.","family":"Joshi","sequence":"additional","affiliation":[{"name":"Novel Drug Design and Discovery Laboratory, Department of Pharmaceutical Chemistry S.E.T.\u2019s College of Pharmacy  Dharwad Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay M.","family":"Kumbar","sequence":"additional","affiliation":[{"name":"Dr. Prabhakar Kore Basic Science Research Center KLE University  Belagavi Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aravind R.","family":"Nesaragi","sequence":"additional","affiliation":[{"name":"Department of Studies in Chemistry Karnatak University Dharwad  Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahadevappa Y.","family":"Kariduraganavar","sequence":"additional","affiliation":[{"name":"Department of Studies in Chemistry Karnatak University Dharwad  Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,9]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(03)00045-X"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/518663"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1816"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2201"},{"key":"e_1_2_7_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200502161"},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/cc020085v"},{"key":"e_1_2_7_1_8_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.44.969"},{"key":"e_1_2_7_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2006.08.019"},{"key":"e_1_2_7_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.09.096"},{"key":"e_1_2_7_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2008.02.013"},{"key":"e_1_2_7_1_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-50532007000600027"},{"key":"e_1_2_7_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-008096519-2.00079-5"},{"key":"e_1_2_7_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20010601)40:11<2004::AID-ANIE2004>3.0.CO;2-5"},{"key":"e_1_2_7_1_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo011148j"},{"key":"e_1_2_7_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20020715)41:14<2596::AID-ANIE2596>3.0.CO;2-4"},{"key":"e_1_2_7_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.11.127"},{"key":"e_1_2_7_1_18_1","first-page":"778","volume":"45","author":"Punna S.","year":"2004","journal-title":"Am. 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