{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T22:23:06Z","timestamp":1782944586365,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A series of gatifloxacin\u20101,2,3\u2010triazole\u2010isatin hybrids <jats:bold>8a\u2013l<\/jats:bold> were designed, synthesized, and screened for their in vitro antimycobacterial activity as well as cytotoxicity toward Chinese Hamster Ovary (CHO) cells. The synthesized hybrids showed considerable activity against MTB H<jats:sub>37<\/jats:sub>Rv and two MDR\u2010MTB strains with minimal inhibitory concentration (MIC) of 0.25\u20138\u2009\u03bcg\/ml, and the hybrid <jats:bold>8a<\/jats:bold> (MIC<jats:sub>MTB H37Rv<\/jats:sub>: 0.25\u2009\u03bcg\/ml and MIC<jats:sub>MDR\u2010MTB<\/jats:sub>: 0.5 and 1\u2009\u03bcg\/ml) was found to be most active against the tested strains, which was not inferior to the parent gatifloxacin (MIC: 0.5, 0.25, and 0.5\u2009\u03bcg\/ml) against all three tested strains, and was \u2265128\u2010fold more active than isoniazid (MIC: \u226564\u2009\u03bcg\/ml) and rifampicin (MIC: &gt;128\u2009\u03bcg\/ml) against the two MDR\u2010MTB strains. Moreover, hybrid <jats:bold>8a<\/jats:bold> (CC<jats:sub>50<\/jats:sub>: 8.0\u2009\u03bcg\/ml) also displayed acceptable cytotoxicity toward CHO cells, and the selectivity index was 32. The structure\u2013activity relationship and structure\u2013cytotoxicity relationship were also enriched.<\/jats:p>","DOI":"10.1002\/ardp.201900135","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T07:00:29Z","timestamp":1566543629000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Gatifloxacin\u20101,2,3\u2010triazole\u2010isatin hybrids and their antimycobacterial activities"],"prefix":"10.1002","volume":"352","author":[{"given":"Zhen","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Pharmacy Bozhou People's Hospital  Bozhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5315-6012","authenticated-orcid":false,"given":"Panfei","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Lianshui County People's Hospital  Lianshui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4577-546X","authenticated-orcid":false,"given":"Bi","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Nuclear Technology and Chemistry and Biology Hubei University of Science and Technology  Xianning China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,22]]},"reference":[{"key":"e_1_2_5_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.09.049"},{"key":"e_1_2_5_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.01.042"},{"key":"e_1_2_5_1_4_1","unstructured":"World Health Organization.Global Tuberculosis Report2018."},{"key":"e_1_2_5_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.06.051"},{"key":"e_1_2_5_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.01.080"},{"key":"e_1_2_5_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2017.07.023"},{"key":"e_1_2_5_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2006.02.065"},{"key":"e_1_2_5_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.05.057"},{"key":"e_1_2_5_1_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.5b00146"},{"key":"e_1_2_5_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201400456"},{"key":"e_1_2_5_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.05.026"},{"key":"e_1_2_5_1_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja402326z"},{"key":"e_1_2_5_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.11.090"},{"key":"e_1_2_5_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.07.025"},{"key":"e_1_2_5_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.12.001"}],"container-title":["Archiv der Pharmazie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fardp.201900135","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ardp.201900135","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ardp.201900135","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ardp.201900135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T16:32:48Z","timestamp":1694190768000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ardp.201900135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,22]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1002\/ardp.201900135"],"URL":"https:\/\/doi.org\/10.1002\/ardp.201900135","archive":["Portico"],"relation":{},"ISSN":["0365-6233","1521-4184"],"issn-type":[{"value":"0365-6233","type":"print"},{"value":"1521-4184","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,22]]},"assertion":[{"value":"2019-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"1900135"}}