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The structures of the newly synthesized pyrazoline derivatives were characterized by Fourier transform\u2010infrared spectroscopy, <jats:sup>1<\/jats:sup>H\u2010\/<jats:sup>13<\/jats:sup>C\u2010nuclear magnetic resonance, and mass spectrometry, and elemental analysis. Compounds <jats:bold>1\u20136<\/jats:bold> showed <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values in the range of 16.4\u2013205.9\u2009nM for hCA I and of 6.08\u201393.21\u2009nM against hCA II. These hydroxyl and amino group\u2010containing compounds generally were competitive inhibitors. The compounds investigated here showed effective hCA I and II inhibitory effects, in the same range as the clinically used acetazolamide, and might be used as leads for generating enzyme inhibitors, possibly targeting other CA isoforms that have not yet been assayed for their interactions with such agents.<\/jats:p>","DOI":"10.1002\/ardp.201900292","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T12:43:24Z","timestamp":1578660204000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Synthesis and characterization of some new pyrazolines and their inhibitory potencies against carbonic anhydrases"],"prefix":"10.1002","volume":"353","author":[{"given":"Gonca","family":"\u00c7elik","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science Karadeniz Technical University Trabzon Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1426-5857","authenticated-orcid":false,"given":"Tayfun","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Giresun University Giresun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"\u015eent\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences of Pharmacy, Faculty of Pharmacy Ibrahim Cecen University Agri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Ekinci","sequence":"additional","affiliation":[{"name":"Department of Agricultural Biotechnology, Faculty of Agriculture Ondokuz May\u0131s University Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2017.02.025"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111648"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.08.040"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/23312009.2016.1141388"},{"key":"e_1_2_7_6_1","first-page":"165","volume":"2","author":"Rahman M. 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