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The syntheses of the new complexes <jats:bold>1b<\/jats:bold> and <jats:bold>1c<\/jats:bold> were described. Ferrocene compound <jats:bold>1a<\/jats:bold> showed the highest activities against <jats:italic>L. major<\/jats:italic> amastigotes and <jats:italic>T. gondii<\/jats:italic> and distinct selectivity for <jats:italic>T. gondii<\/jats:italic> cells when compared with the activity against nonmalignant Vero cells. The ferrocene derivatives <jats:bold>1a\u2013c<\/jats:bold> are generally more active against the <jats:italic>L. major<\/jats:italic> amastigotes and the <jats:italic>T. gondii<\/jats:italic> tachyzoites than the other tested anisyl gold complexes and the approved drugs atovaquone and amphotericin B. Compounds <jats:bold>1a<\/jats:bold> and <jats:bold>1e<\/jats:bold> showed the highest selectivities for <jats:italic>L. major<\/jats:italic> amastigotes. Compounds <jats:bold>1d<\/jats:bold> and <jats:bold>1f<\/jats:bold> showed the highest selectivities for <jats:italic>L. major<\/jats:italic> promastigotes; <jats:bold>1f<\/jats:bold> was the most active compound against <jats:italic>L. major<\/jats:italic> promastigotes of this series of compounds. The 3,4,5\u2010trimethoxyphenyl analog <jats:bold>1b<\/jats:bold> also exhibited a much greater selectivity for <jats:italic>T. b. brucei<\/jats:italic> cells when compared with its activity against human HeLa cells.<\/jats:p>","DOI":"10.1002\/ardp.201900363","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T10:49:30Z","timestamp":1583750970000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Evaluation of the antiparasitic activities of imidazol\u20102\u2010ylidene\u2013gold(I) complexes"],"prefix":"10.1002","volume":"353","author":[{"given":"Waleed S.","family":"Koko","sequence":"first","affiliation":[{"name":"College of Science and Arts in Ar Rass Qassim University  Ar Rass Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Jentzsch","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Parasitology University of Bayreuth  Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein","family":"Kalie","sequence":"additional","affiliation":[{"name":"Organic Chemistry Laboratory University of Bayreuth  Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Schobert","sequence":"additional","affiliation":[{"name":"Organic Chemistry Laboratory University of Bayreuth  Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Ersfeld","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Parasitology University of Bayreuth  Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim S.","family":"Al Nasr","sequence":"additional","affiliation":[{"name":"College of Science and Arts in Ar Rass Qassim University  Ar Rass Saudi Arabia"},{"name":"College of Science and Arts in Unaizah Qassim University  Unaizah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq A.","family":"Khan","sequence":"additional","affiliation":[{"name":"College of Applied Health Sciences in Ar Rass Qassim University  Ar Rass Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7305-346X","authenticated-orcid":false,"given":"Bernhard","family":"Biersack","sequence":"additional","affiliation":[{"name":"Organic Chemistry Laboratory University of Bayreuth  Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22010058"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed2030036"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5DT03919C"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr980431o"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.12.003"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-011-0997-9"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00570B"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm300428v"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7MD00269F"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201805727"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8mt00306h"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2017.05.001"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2005.09.054"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules13112900"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.02.046"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.18831\/djchem.org\/2016041006"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.04.064"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201400049"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201604246"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01014-09"},{"key":"e_1_2_6_22_1","first-page":"e82389","volume":"12","author":"Sarouey L. 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