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The most potent compounds are not substituted at the adamantane and bear an OH or NH<jats:sub>2<\/jats:sub> substituent at the phthalimide (compounds <jats:bold>3<\/jats:bold> and <jats:bold>5<\/jats:bold>). The antiproliferative activities of compounds <jats:bold>3<\/jats:bold> and <jats:bold>5<\/jats:bold> are in the micromolar range, much higher than the one of thalidomide. A minor antiviral activity against cytomegalovirus and varicella\u2010zoster virus was found for compounds <jats:bold>3<\/jats:bold> and <jats:bold>5<\/jats:bold>, but these compounds lacked selectivity. The results presented are important for the rational design of the next\u2010generation compounds with anticancer and antiviral activities.<\/jats:p>","DOI":"10.1002\/ardp.202000024","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T07:46:31Z","timestamp":1586850391000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Substituted adamantylphthalimides: Synthesis, antiviral and antiproliferative activity"],"prefix":"10.1002","volume":"353","author":[{"given":"Leo","family":"Mandi\u0107","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry and Biochemistry Ru\u0111er Bo\u0161kovi\u0107 Institute  Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Ben\u010di\u0107","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine Ru\u0111er Bo\u0161kovi\u0107 Institute  Zagreb 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