{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T12:28:53Z","timestamp":1775219333271,"version":"3.50.1"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A series of 3\u2010{2\u2010[1\u2010acetyl\u20105\u2010(substitutedphenyl)\u20104,5\u2010dihydropyrazol\u20103\u2010yl]hydrazinylidene}\u20101,3\u2010dihydro\u20102<jats:italic>H<\/jats:italic>\u2010indol\u20102\u2010ones <jats:bold>24\u201343<\/jats:bold> was synthesized using an appropriate synthetic route and evaluated experimentally by the maximal electroshock test. These compounds were evaluated for antidepressant and antianxiety activities. The most active compound, 3\u2010{2\u2010[1\u2010acetyl\u20105\u2010(4\u2010chlorophenyl)\u20104,5\u2010dihydropyrazol\u20103\u2010yl]hydrazinylidene}\u20101,3\u2010dihydro\u20102<jats:italic>H<\/jats:italic>\u2010indol\u20102\u2010one <jats:bold>25<\/jats:bold>, exhibited an ED<jats:sub>50<\/jats:sub> of 13.19\u2009mmol\/kg, a TD<jats:sub>50<\/jats:sub> of 43.49\u2009mmol\/kg, and a high protective index of 3.29, compared with the standard drug diazepam. To get insights into the intermolecular interactions, molecular docking studies were performed at the active site of the GABA<jats:sub>A<\/jats:sub> receptor and the MAO\u2010A enzyme. Molecular docking studies are also in agreement with the pharmacological evaluation with potent compounds, exhibiting docking scores of \u22121.5180 and 0.7458 for the GABA<jats:sub>A<\/jats:sub> receptor and MAO\u2010A, respectively. The 3D\u2010QSAR analysis was carried out by Vlife MDS engine 4.3.1, and a statistically reliable model with good predictive power (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.7523, <jats:italic>q<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.3773) was achieved. The 3D\u2010QSAR plots gave insights into the structure\u2013activity relationship of these compounds, which may aid in the design of potent benzopyrrole derivatives as anticonvulsant agents. So, our research can make a great impact on those medicinal chemists who work on the development of anticonvulsant agents.<\/jats:p>","DOI":"10.1002\/ardp.202000100","type":"journal-article","created":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T11:27:30Z","timestamp":1601206050000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Development of novel indole\u2010linked pyrazoles as anticonvulsant agents: A molecular hybridization approach"],"prefix":"10.1002","volume":"354","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9437-6882","authenticated-orcid":false,"given":"Deweshri R.","family":"Kerzare","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry Kamla Nehru College of Pharmacy, Butibori  Nagpur India"},{"name":"Department of Pharmaceutical Sciences Rashtrasant Tukadoji Maharaj Nagpur University  Nagpur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil S.","family":"Menghani","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Yenepoya Pharmacy College and Research Centre Yenepoya, Derlakatte  Mangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilesh R.","family":"Rarokar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Rashtrasant Tukadoji Maharaj Nagpur University  Nagpur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pramod B.","family":"Khedekar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Rashtrasant Tukadoji Maharaj Nagpur University  Nagpur India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Epilepsy and Quality of Life","author":"Kendrick A. 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