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These synthesized novel derivatives were found to be effective inhibitor molecules for \u03b1\u2010glycosidase (\u03b1\u2010GLY), human carbonic anhydrase (<jats:italic>h<\/jats:italic>CA), and acetylcholinesterase (AChE), with <jats:italic>K<\/jats:italic><jats:sub>I<\/jats:sub> values in the range of 426.84\u2009\u00b1\u200958.42\u2013708.61\u2009\u00b1\u2009122.67\u2009nM for \u03b1\u2010GLY, 450.37\u2009\u00b1\u200950.35\u20131,094.34\u2009\u00b1\u2009111.37\u2009nM for <jats:italic>h<\/jats:italic>CA I, 504.37\u2009\u00b1\u200957.22\u20131,205.36\u2009\u00b1\u2009195.47\u2009nM for <jats:italic>h<\/jats:italic>CA II, and 68.28\u2009\u00b1\u200910.26\u2013193.74\u2009\u00b1\u200919.75\u2009nM for AChE. Among the synthesized novel compounds, several lead compounds were investigated against the tested metabolic enzymes. More specifically, <jats:bold>ST11<\/jats:bold> (4\u2010[3\u2010(perfluorophenyl)triaz\u20101\u2010en\u20101\u2010yl]\u2010<jats:italic>N<\/jats:italic>\u2010(thiazol\u20102\u2010yl)benzenesulfonamide) showed a highly efficient inhibition profile against <jats:italic>h<\/jats:italic>CA I, <jats:italic>h<\/jats:italic>CA II, and AChE, with <jats:italic>K<\/jats:italic><jats:sub>I<\/jats:sub> values of 450.37\u2009\u00b1\u200950.35, 504.37\u2009\u00b1\u200957.22, and 68.28\u2009\u00b1\u200910.26\u2009nM, respectively. Due to its significant biological inhibitory potency, this derivative may be considered as an interesting lead compound against these enzymes.<\/jats:p>","DOI":"10.1002\/ardp.202000102","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T06:37:10Z","timestamp":1591943830000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Synthesis, characterization, biological evaluation, and in silico studies of novel 1,3\u2010diaryltriazene\u2010substituted sulfathiazole derivatives"],"prefix":"10.1002","volume":"353","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4677-8104","authenticated-orcid":false,"given":"Mesut","family":"I\u015f\u0131k","sequence":"first","affiliation":[{"name":"Department of Pharmacy Services, Vocational School of Health Services Harran University \u015eanl\u0131urfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4506-5265","authenticated-orcid":false,"given":"S\u00fcleyman","family":"Akocak","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Ad\u0131yaman University Ad\u0131yaman Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0578-2761","authenticated-orcid":false,"given":"Nabih","family":"Lolak","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Ad\u0131yaman University Ad\u0131yaman Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3171-0633","authenticated-orcid":false,"given":"Parham","family":"Taslimi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Faculty of Science Bart\u0131n University Bart\u0131n Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2932-2789","authenticated-orcid":false,"given":"C\u00fcneyt","family":"T\u00fcrke\u015f","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy Erzincan Binali Y\u0131ld\u0131r\u0131m University Erzincan Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-1668","authenticated-orcid":false,"given":"\u0130lhami","family":"G\u00fcl\u00e7in","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Durgun","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Arts and Sciences Harran University \u015eanl\u0131urfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3667-6902","authenticated-orcid":false,"given":"\u015e\u00fckr\u00fc","family":"Beydemir","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy Anadolu University Eski\u015fehir Turkey"},{"name":"The Rectorate of Bilecik \u015eeyh Edebali University Bilecik Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2007.08.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2019.1700240"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2018.1515933"},{"key":"e_1_2_7_5_1","author":"T\u00fcrke\u015f C.","journal-title":"J. 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