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It is estimated by the World Health Organization that over 40% of the world's population lives in areas at risk for malarial transmission, and around half a million people succumb to this infectious disease annually, which is related to the rapid spread of drug\u2010resistant parasite strains. Indole derivatives, which possess broad\u2010spectrum pharmacological properties, play a crucial role in the discovery of new drugs. Many indole derivatives exhibited potential in vitro and in vivo activity against both drug\u2010sensitive and drug\u2010resistant malaria, suggesting that the indole moiety is a useful template for the development of novel antimalarial agents. This review outlines the advances in indole alkaloids and hybrids with antimalarial potential in the recent decade.<\/jats:p>","DOI":"10.1002\/ardp.202000131","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T13:14:22Z","timestamp":1597238062000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["The antimalarial activity of indole alkaloids and hybrids"],"prefix":"10.1002","volume":"353","author":[{"given":"Jue\u2010Ying","family":"Li","sequence":"first","affiliation":[{"name":"Ultrasonography Department, The Central Hospital of Wuhan, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8624-094X","authenticated-orcid":false,"given":"Xiao\u2010Feng","family":"Sun","sequence":"additional","affiliation":[{"name":"Ultrasonography Department, The Central Hospital of Wuhan, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Ultrasonography Department, The Central Hospital of Wuhan, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Yu","sequence":"additional","affiliation":[{"name":"Ultrasonography Department, The Central Hospital of Wuhan, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ultrasonography Department, The Central Hospital of Wuhan, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu\u2010Juan","family":"Huang","sequence":"additional","affiliation":[{"name":"Ultrasonography Department, The Central Hospital of Wuhan, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng\u2010Xia","family":"Jiang","sequence":"additional","affiliation":[{"name":"Ultrasonography Department, The Central Hospital of Wuhan, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111983"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201900350"},{"key":"e_1_2_7_4_1","unstructured":"World Health Organization. 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