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Due to the development of resistance to the current therapy, there is an urgent need for less toxic and more effective antifungal agents. In this study, we describe the antifungal activity against <jats:italic>Cryptococcus<\/jats:italic> spp. of an aqueous seed extract from <jats:italic>Allamanda polyantha<\/jats:italic> (ASEAP) and two iridoids, plumieride and plumieridine, isolated from this extract with an antifungal activity. The capsule formation and the morphological alterations were evaluated using fluorescent microscopy. The cytotoxic activity was also investigated. The minimal inhibitory concentration (MIC) values of ASEAP for <jats:italic>Cryptococcus gattii<\/jats:italic> were 70 and 36\u2009\u00b5g\/ml (for the R265 and R272 strains, respectively) and 563\u2009\u00b5g\/ml for <jats:italic>Cryptococcus neoformans<\/jats:italic> H99. ASEAP inhibited <jats:italic>C. neoformans<\/jats:italic> H99 capsule formation, an important virulence factor, and decreased the cell body size for both the <jats:italic>C. gattii<\/jats:italic> strains. H99 cells also presented morphological alterations, with defects in bud detachment and nuclear fragmentation. Plumieride and plumieridine presented higher MIC values than ASEAP, indicating that other compounds might contribute to antifungal activity and\/or that combination of the compounds results in a higher antifungal activity.<\/jats:p>","DOI":"10.1002\/ardp.202000133","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T08:54:29Z","timestamp":1594198469000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Antifungal activity of <i>Allamanda polyantha<\/i> seed extract and its iridoids promote morphological alterations in <i>Cryptococcus<\/i> spp."],"prefix":"10.1002","volume":"353","author":[{"given":"Fernanda R.","family":"Bresciani","sequence":"first","affiliation":[{"name":"Postgraduate Program in Cellular and Molecular Biology Federal University of Rio Grande do Sul Porto Alegre Rio Grande do Sul 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