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These compounds were synthesized using a well\u2010known approach, based on the condensation of ethyl acetoacetate with thiazolylhydrazines, and characterized by various spectroscopic and analytical techniques. The entire set of compounds displayed a moderate\u2010to\u2010excellent inhibitory activity against ACE. In particular, compound <jats:bold>4i<\/jats:bold> was found to be the most potent ACE inhibitor and was further studied for cardioprotective effects against isoproterenol (ISO)\u2010induced myocardial infarction (MI) in rats. Compound <jats:bold>4i<\/jats:bold> improved the cardiac function and prevented cardiac injury induced by ISO in Sprague Dawley rats. The levels of oxidative stress and proinflammatory cytokines were also restored to near normal by <jats:bold>4i<\/jats:bold> as compared with the ISO group. In the Western blot analysis, compound <jats:bold>4i<\/jats:bold> prevented mitochondrial apoptosis after MI by downregulating the expression of cleaved caspase\u20103 and Bax, with the upregulation of Bcl\u20102, as compared with the ISO group.<\/jats:p>","DOI":"10.1002\/ardp.202000140","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T02:51:21Z","timestamp":1598410281000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Novel thiazole\u2013pyrazolone hybrids as potent ACE inhibitors and their cardioprotective effect on isoproterenol\u2010induced myocardial infarction"],"prefix":"10.1002","volume":"353","author":[{"given":"Hongwen","family":"You","sequence":"first","affiliation":[{"name":"Department of Cardiology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyou","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Oncology, Jinan Central Hospital, Cheeloo College of Medicine Shandong University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4462-2587","authenticated-orcid":false,"given":"Guoying","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Jinan Central Hospital, Cheeloo College of Medicine Shandong University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12383"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2007.03.007"},{"key":"e_1_2_7_4_1","first-page":"251","volume":"25","author":"Hu S. 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