{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T21:00:07Z","timestamp":1788642007806,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,7,19]],"date-time":"2020-07-19T00:00:00Z","timestamp":1595116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Archiv der Pharmazie"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>New drugs are constantly in demand, and nature's biodiversity is a rich source of new compounds for therapeutic applications. Synthetic peptides based on the transcriptome analysis of scorpion venoms of <jats:italic>Tityus obscurus, Opisthacanthus cayaporum<\/jats:italic>, and <jats:italic>Hadrurus gertschi<\/jats:italic> were assayed for their cytotoxic and antiretroviral activity. The <jats:italic>Tityus obscurus<\/jats:italic> scorpion\u2010derived synthetic peptide (FFGTLFKLGSKLIPGVMKLFSKKKER), in concentrations ranging from 6.24 to 0.39\u2009\u03bcM, proved to be the most active one against simian immunodeficiency virus (SIV) replication in the HUT\u201078 cell line and in primary human leukocytes, with the lowest toxicity for these cells. The immune cellular response evaluated in primary human leukocytes treated with the most promising peptide and challenged with SIV infection exhibited production of cytokines such as interleukin (IL)\u20104, IL\u20106, IL\u20108, IL\u201010, and interferon\u2010\u03b3, which could be involved in cell defense mechanisms to overcome viral infection through proinflammatory and anti\u2010inflammatory pathways, similar to those evoked for triggering the mechanisms exerted by antiviral restriction factors.<\/jats:p>","DOI":"10.1002\/ardp.202000151","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T06:53:12Z","timestamp":1595227992000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Antiretroviral and cytotoxic activities of <i>Tityus obscurus<\/i> synthetic peptide"],"prefix":"10.1002","volume":"353","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5254-0151","authenticated-orcid":false,"given":"Elida C. G.","family":"da Mata","sequence":"first","affiliation":[{"name":"Laboratory of Bioprospection, Faculty of Health Sciences University of Brasilia  Brasilia Brazil"},{"name":"Laboratory of Neuropharmacology, Institute of Biological Sciences University of Brasilia  Brasilia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Ombredane","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Compounds and Nanobiotechnology, Faculty of Ceilandia University of Brasilia  Brasilia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziella A.","family":"Joanitti","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Compounds and Nanobiotechnology, Faculty of Ceilandia University of Brasilia  Brasilia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. I. B.","family":"Kanzaki","sequence":"additional","affiliation":[{"name":"Laboratory of Bioprospection, Faculty of Health Sciences University of Brasilia  Brasilia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth F.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Laboratory of Neuropharmacology, Institute of Biological Sciences University of Brasilia  Brasilia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540121.2018.1456642"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2017.05.001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/16549716.2019.1662685"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08854-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23030533"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2018.02.002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6024"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12033-017-0056-1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2017.06.123"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389200216666150206125727"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2018.1421171"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.06.009"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40409-016-0089-0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.21425"},{"key":"e_1_2_8_16_1","first-page":"259","volume":"20","author":"Zabihollahi R.","year":"2016","journal-title":"Iran. Biomed. J."},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins8050124"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034947"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-015-0276-6"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.11.013"},{"key":"e_1_2_8_21_1","first-page":"38","volume":"2009","author":"Souza C. A. R.","year":"1987","journal-title":"Zootaxa"},{"key":"e_1_2_8_22_1","first-page":"1","volume":"75","author":"Louren\u00e7o W. R.","year":"2008","journal-title":"Euscorpius"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1678-9199-20-3"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40409-018-0139-x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2013.04.021"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins8010002"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00273"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins10060219"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01844"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2019.05.005"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01226-15"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(90)90379-A"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins9080244"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2017.03.005"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.05.002"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12717"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120231"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00235-18"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3MR0717-307R"},{"key":"e_1_2_8_40_1","first-page":"1","volume":"3","author":"Mata E. C. G.","year":"2019","journal-title":"Microbiol. Infect. Dis."},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2009.04.010"}],"container-title":["Archiv der Pharmazie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fardp.202000151","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ardp.202000151","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ardp.202000151","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ardp.202000151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T23:05:57Z","timestamp":1693868757000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ardp.202000151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,19]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1002\/ardp.202000151"],"URL":"https:\/\/doi.org\/10.1002\/ardp.202000151","archive":["Portico"],"relation":{},"ISSN":["0365-6233","1521-4184"],"issn-type":[{"value":"0365-6233","type":"print"},{"value":"1521-4184","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,19]]},"assertion":[{"value":"2020-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2000151"}}