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These compounds were obtained through the coupling reaction of the starting carboxylic acids with appropriate amines. The initial anticonvulsant screening was performed in mice (intraperitoneal administration) using the maximal electroshock seizure (MES) and the subcutaneous pentylenetetrazole (scPTZ) seizure models. The most promising compound <jats:bold>6<\/jats:bold> showed more potent protection in the MES and scPTZ tests than valproic acid, which is still recognized as one of the most relevant first\u2010line anticonvulsants. The structure\u2013activity relationship analysis revealed that the presence of the pyrrolidine\u20102,5\u2010dione ring is important but not indispensable to retain anticonvulsant activity. Additionally, compound <jats:bold>6<\/jats:bold> showed potent antinociceptive properties in the oxaliplatin\u2010induced neuropathic pain model in mice. The most plausible mechanism of action for compound <jats:bold>6<\/jats:bold> may result from its influence on the neuronal sodium channel (Site 2) and the high\u2010voltage\u2010activated L\u2010type calcium channel.<\/jats:p>","DOI":"10.1002\/ardp.202000225","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T07:06:27Z","timestamp":1600326387000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Synthesis, anticonvulsant, and antinociceptive activity of new 3\u2010(3\u2010methyl\u20102,5\u2010dioxo\u20103\u2010phenylpyrrolidin\u20101\u2010yl)propanamides and 3\u2010phenyl\u2010butanamides"],"prefix":"10.1002","volume":"354","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1414-2256","authenticated-orcid":false,"given":"Jolanta","family":"Obniska","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry, Faculty of Pharmacy Jagiellonian University Medical College  Cracow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3801-928X","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"G\u00f3ra","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Faculty of Pharmacy Jagiellonian University Medical College  Cracow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0190-1682","authenticated-orcid":false,"given":"Anna","family":"Rapacz","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics, Faculty of Pharmacy Jagiellonian University Medical College  Cracow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0614-5393","authenticated-orcid":false,"given":"Kinga","family":"Sa\u0142at","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics, Faculty of Pharmacy Jagiellonian University Medical College  Cracow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabina","family":"Rybka","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Faculty of Pharmacy Jagiellonian University Medical College  Cracow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9738-3359","authenticated-orcid":false,"given":"Micha\u0142","family":"Abram","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Faculty of Pharmacy Jagiellonian University Medical College  Cracow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6602-3825","authenticated-orcid":false,"given":"Marcin","family":"Jakubiec","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Faculty of Pharmacy Jagiellonian University Medical College  Cracow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2103-371X","authenticated-orcid":false,"given":"Krzysztof","family":"Kami\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Faculty of Pharmacy Jagiellonian University Medical College  Cracow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2016.11.022"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X16666180510151241"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.07.029"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2016.04.066"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.12.027"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201600368"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2016.02.026"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.07.017"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.04.033"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01114"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00578"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00476"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1430"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03712.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3998\/ark.5550190.0004.502","volume":"10","author":"Katritzky A. 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