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Their chemical structures were characterized by <jats:sup>1<\/jats:sup>H nuclear magnetic resonance (NMR), <jats:sup>13<\/jats:sup>C NMR, and high\u2010resolution mass spectra. The newly synthesized compounds were evaluated in terms of acetylcholineasterase (AChE) and human carbonic anhydrases (hCA) I and II isoenzymes inhibitory activities. According to the AChE inhibition results, the <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values of the compounds <jats:bold>1<\/jats:bold>\u2013<jats:bold>9<\/jats:bold> were in the range of 19.9\u2009\u00b1\u20091.5 to 96.5\u2009\u00b1\u200920.7\u2009nM against AChE. Tacrine was used as the reference drug and its <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> value was 49.2\u2009\u00b1\u20092.7\u2009nM against AChE. The <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values of the compounds <jats:bold>1<\/jats:bold>\u2013<jats:bold>9<\/jats:bold> were in the range of 10.2\u2009\u00b1\u20092.6 to 101.4\u2009\u00b1\u200927.8\u2009nM against hCA I, whereas they were 18.3\u2009\u00b1\u20094.4 to 48.1\u2009\u00b1\u20094.5\u2009nM against hCA II. Acetazolamide was used as a reference drug and its <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values were 72.2\u2009\u00b1\u20095.4 and 52.2\u2009\u00b1\u20095.7\u2009nM against hCA I and hCA II, respectively. The most active compounds, <jats:bold>1<\/jats:bold> (nonsubstituted) against AChE, <jats:bold>5<\/jats:bold> (4\u2010ethoxy\u2010substituted) against hCA I, and <jats:bold>8<\/jats:bold> (4\u2010bromo\u2010substituted) against hCA II, were chosen and docked at the binding sites of these enzymes to explain the inhibitory activities of the series. The newly synthesized compounds presented satisfactory pharmacokinetic properties via the estimation of ADME properties.<\/jats:p>","DOI":"10.1002\/ardp.202000243","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T07:42:28Z","timestamp":1601278948000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Synthesis and in silico studies of triazene\u2010substituted sulfamerazine derivatives as acetylcholinesterase and carbonic anhydrases inhibitors"],"prefix":"10.1002","volume":"354","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5676-2045","authenticated-orcid":false,"given":"Sinan","family":"Bilginer","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Ataturk University Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halise I.","family":"Gul","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Ataturk University Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baris","family":"Anil","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Ataturk University Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeliz","family":"Demir","sequence":"additional","affiliation":[{"name":"Nihat Delibalta G\u00f6le Vocational High School Ardahan University Ardahan Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilhami","family":"Gulcin","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Ataturk University Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3934\/Neuroscience.2018.1.74","volume":"5","author":"Nguyen K. 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