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After preparing dimethoxy conduritol\u2010B as a key compound, regiospecific bromination of the alkene moiety of dimethoxy conduritol\u2010B and acid\u2010catalyzed ring opening of dimethoxydiacetate conduritol\u2010B epoxide with Ac<jats:sub>2<\/jats:sub>O afforded the desired new <jats:italic>chiro<\/jats:italic>\u2010inositol derivatives and <jats:italic>scyllo<\/jats:italic>\u2010inositol derivative, respectively. Spectroscopic methods were employed for the characterization of all synthesized compounds. The novel inositols (<jats:bold>11<\/jats:bold>\u2013<jats:bold>17<\/jats:bold>) had effective inhibition profiles against human carbonic anhydrase isoenzymes I and II (hCA I and II) and acetylcholinesterase (AChE). The novel inositols <jats:bold>11<\/jats:bold>\u2013<jats:bold>17<\/jats:bold> were found to be effective inhibitors against AChE, hCA I, and hCA II enzymes. <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values were calculated in the range of 87.59\u2009\u00b1\u20097.011 to 237.95\u2009\u00b1\u200917.75\u2009\u03bcM for hCA I, 65.08\u2009\u00b1\u200912.39 to 538.98\u2009\u00b1\u200961.26\u2009\u03bcM for hCA II, and 193.28\u2009\u00b1\u200943.13 to 765.08\u2009\u00b1\u2009209.77\u2009\u03bcM for AChE, respectively. Also, due to the inhibitory effects of the novel inositols <jats:bold>11<\/jats:bold>\u2013<jats:bold>17<\/jats:bold> against the tested enzymes, these novel inositols are potential drug candidates to treat some diseases such as glaucoma, epilepsy, leukemia, and Alzheimer's disease.<\/jats:p>","DOI":"10.1002\/ardp.202000254","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T15:08:31Z","timestamp":1601478511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Concise syntheses and some biological activities of <scp>dl<\/scp>\u20102,5\u2010di\u2010<i>O<\/i>\u2010methyl\u2010<i>chiro<\/i>\u2010inositol, <scp>dl<\/scp>\u20101,4\u2010di\u2010<i>O<\/i>\u2010methyl\u2010<i>scyllo<\/i>\u2010inositol, and <scp>dl<\/scp>\u20101,6\u2010dibromo\u20101,6\u2010dideoxy\u20102,5\u2010di\u2010<i>O<\/i>\u2010methyl\u2010<i>chiro<\/i>\u2010inositol"],"prefix":"10.1002","volume":"354","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2729-2168","authenticated-orcid":false,"given":"Kadir","family":"Aksu","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences and Arts Ordu University  Ordu Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5453-0953","authenticated-orcid":false,"given":"Hulya","family":"Akincioglu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences and Arts Agri Ibrahim Cecen University  Agri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-1668","authenticated-orcid":false,"given":"Ilhami","family":"Gulcin","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences Ataturk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6242-2589","authenticated-orcid":false,"given":"Latif","family":"Kelebekli","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences and Arts Ordu University  Ordu Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201502227"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr1004138"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2011.01.012"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr0200724"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1586\/17512433.2014.925795"},{"key":"e_1_2_7_7_1","first-page":"1295","volume":"13","author":"Nestler J. 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