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Obtained data revealed that all the synthesized compounds were more potent as compared with the used standard inhibitors against studied target enzymes. Among the synthesized compounds, 4\u2010fluoro derivative (<jats:bold>10f<\/jats:bold>) against hCA I, 4\u2010chloro derivative (<jats:bold>10i<\/jats:bold>) against hCA II, 3\u2010fluoro derivative (<jats:bold>10e<\/jats:bold>) against acetylcholinesterase and butyrylcholinesterase, and 3\u2010bromo derivative (<jats:bold>10k<\/jats:bold>) against \u03b1\u2010glucosidase were the most potent compounds with inhibitory activity around 1.8\u2010 to 7.37\u2010fold better than standard inhibitors. Furthermore, docking studies of these compounds were performed at the active site of their target enzymes.<\/jats:p>","DOI":"10.1002\/ardp.202000471","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T13:06:03Z","timestamp":1621256763000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["New quinoxalin\u20101,3,4\u2010oxadiazole derivatives: Synthesis, characterization, in vitro biological evaluations, and molecular modeling studies"],"prefix":"10.1002","volume":"354","author":[{"given":"Roghieh","family":"Mirzazadeh","sequence":"first","affiliation":[{"name":"Department of Biochemistry Pasteur Institute of Iran Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad S.","family":"Asgari","sequence":"additional","affiliation":[{"name":"Department of Chemistry Iran University of Science and Technology Tehran 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